Frequent use of antibiotics is thought to create selection pressure by clearing susceptible bacteria and allowing resistant bacteria to spread in a community. A cluster-randomized trial comparing 2 different frequencies of mass azithromycin distributions for trachoma provided a convenient experiment for determining the causal relationship between antibiotic consumption and antibiotic resistance.

中文翻译：

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抗生素选择压力对鼻咽大环内酯抗药性的影响：一项集群随机试验。

据认为，经常使用抗生素会通过清除易感细菌并使耐药菌在社区中传播而产生选择压力。一项比较2种不同频率阿奇霉素沙眼分布的随机试验，为确定抗生素消耗与耐药性之间的因果关系提供了方便的实验。