The treatment for leishmaniasis and Chagas disease can be hard and painful, such that many patients give up on the treatment. In order to find an alternative path for the treatment of these diseases, researchers are using natural products to fight these parasites. The aim of this study was to evaluate the antiprotozoan and cytotoxic activities of red propolis samples collected from different Brazilian states and seasons whilst searching for possible activity differences. We also compared the red propolis results with the ones obtained for the plant resin extract collected from Dalbergia ecastaphyllum trees. The hydroethanolic red propolis extracts from Pernambuco and Alagoas, and the D. ecastaphyllum resin were evaluated regarding their antileishmanial, antitrypanosomal and cytotoxic activity. All extracts showed antiprotozoan and cytotoxic activity. RP-PER showed to be more cytotoxic against protozoan parasites and fibroblast cells. All propolis extracts showed a higher cytotoxic activity when compared to resin extracts. The propolis sample collected in Pernambuco during the rainy season killed the parasites with lower concentrations than the sample collected in the dry season. The IC₅₀ observed against the parasites could be used without high fibroblast cell damage.

利什曼病和恰加斯病的治疗可能是艰难而痛苦的，因此许多患者放弃了该治疗。为了找到治疗这些疾病的替代途径，研究人员正在使用天然产物对抗这些寄生虫。这项研究的目的是评估从巴西不同州和季节采集的红色蜂胶样品的原生动物和细胞毒活性，同时寻找可能的活性差异。我们还比较了红色蜂胶的结果和从黄檀木中提取的植物树脂提取物获得的结果。伯南布哥州和阿拉戈斯州的水乙醇红色蜂胶提取物，以及D. ecastaphyllum对树脂进行了抗疟原虫，抗锥虫和细胞毒活性的评估。所有提取物均表现出抗原生动物和细胞毒活性。RP-PER对原虫寄生虫和成纤维细胞具有更强的细胞毒性。与树脂提取物相比，所有蜂胶提取物均显示出更高的细胞毒活性。雨季在伯南布哥州采集的蜂胶样品杀死的寄生虫的浓度低于旱季时采集的蜂胶的浓度。可以观察到针对寄生虫观察到的IC _50，而不会造成高度的成纤维细胞损伤。