The aim of this study was to evaluate the anti-edematogenic activity of X. americana L. (HEXA) hydroethanolic extract in ear edema models (acute and chronic) induced by croton oil and by different phlogistic agents (arachidonic acid, capsaicin, phenol and histamine), identifying the possible anti-edematogenic mechanism. HEXA demonstrated a significant anti-edematogenic effect at concentrations of 100–500 μg/ear in ear edema induced by croton oil with higher inhibition of edema of 39.37. However, the concentrations of 100 and 200 μg/ear were taken as a standard, demonstrating the effect in the chronic model induced by croton oil with inhibition of 61.62% and 48.74%. In the AA-induced ear edema model, HEXA showed inhibition of: 24.45% and 32.31%; capsaicin inhibition of 72.72% and 47.57%; phenol inhibition of 34% and 20.1%; and histamine inhibition of 31.8% and 21.62%. Then, the results were showed that HEXA demonstrated an anti-edematogenic effect in acute and chronic inflammation models, demonstrating a probable mechanism of action by the inhibition or modulation of key mediators of the inflammatory process. The chemical profile and presence of flavonoids guaranteeing a profile of activity similar to natural drugs that act or modulate the production of mediators of inflammations.

这项研究的目的是评估巴豆油和不同的发炎药（花生四烯酸，辣椒素，苯酚和组胺），确定可能的抗水肿机理。HEXA在巴豆油引起的耳部水肿中浓度为100–500μg/ ear时显示出显着的抗水肿作用，对水肿的抑制作用更高，为39.37。但是，以100和200μg/耳的浓度为标准，证明在巴豆油诱导的慢性模型中，抑制作用为61.62％和48.74％。在AA引起的耳部水肿模型中，HEXA显示出抑制作用：24.45％和32.31％; 辣椒素抑制率分别为72.72％和47.57％；苯酚抑制率分别为34％和20.1％；组胺抑制率分别为31.8％和21.62％。然后，结果表明，HEXA在急性和慢性炎症模型中均显示出抗水肿作用，通过抑制或调节炎症过程的关键介质，证明了其可能的作用机理。类黄酮的化学特征和存在保证了与天然药物相似的活性特征，所述天然药物起或调节炎症介质的产生。