Electrochemical Determination of Neurotransmitters at Crown Ether Modified Carbon Nanotube Composite: Application for Sub‐nano‐sensing of Serotonin in Human Serum,Electroanalysis

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Electrochemical Determination of Neurotransmitters at Crown Ether Modified Carbon Nanotube Composite: Application for Sub‐nano‐sensing of Serotonin in Human Serum
Electroanalysis ( IF 2.7 ) Pub Date : 2018-03-30 , DOI: 10.1002/elan.201800065
Nada F. Atta ₁ , Yousef M. Ahmed ₁ , Ahmed Galal ₁

Affiliation

We propose an electrochemical sensor based on applying two successive thin layers from a mixture of multiwalled carbon nanotubes‐ionic liquid crystal and crown ether at glassy carbon electrode surface (GC/(CNTs‐ILC)/Crown). The sensor was used for sensitive determination of neurotransmitters based on effective synergism between its components. The compact conducting surface of (CNTs‐ILC) with large surface area allowed the assembling of stable host‐guest inclusion complexes between crown ethers and neurotransmitters. The GC/(CNTs‐ILC)/Crown exhibited excellent electro‐catalytic activity toward the determination of serotonin (ST) in a wide linear dynamic range: 0.005 μmol L⁻¹ to 100 μmol L⁻¹. In the concentration range 0.005 μmol L⁻¹ to 1 μmol L⁻¹, the detection limit is 2.03×10⁻¹⁰ mol L⁻¹ and quantification limit is 6.78×10⁻¹⁰ mol L⁻¹ with correlation coefficient 0.999. The sensor was successfully applied for ST detection in human serum samples with satisfied recovery results. The sensor showed excellent analytical performance for the determination of ST in terms of low detection limit, good sensitivity and reproducibility. Furthermore excellent anti‐interference ability and simultaneous determination of ST in presence of other compounds as ascorbic acid, dopamine and antidepressant drug were achieved.

中文翻译：

冠醚改性碳纳米管复合材料上神经递质的电化学测定：在人血清中血清素亚纳米传感中的应用

我们提出了一种电化学传感器，该传感器基于在玻璃碳电极表面（GC /（CNTs-ILC）/ Crown）上从多壁碳纳米管离子液晶和冠醚的混合物中连续施加两层薄层。该传感器基于其组件之间的有效协同作用，用于神经递质的灵敏测定。（CNTs - ILC）的致密导电表面具有大的表面积，可以在冠醚和神经递质之间组装稳定的主客体包涵体。GC /（CNTs-ILC）/ Crown在很宽的线性动态范围内（0.005μmolL ^-1至100μmolL ^-1）对血清素（ST）的测定具有出色的电催化活性。在0.005μmolL ^-1的浓度范围内达到1μmolL ^-1时，检出限为2.03×10 ^-10 mol L ^-1，定量限为6.78×10 ^-10 mol L ^-1，相关系数为0.999。该传感器已成功用于人体血清样品中的ST检测，回收率令人满意。该传感器在低检出限，良好的灵敏度和可重复性方面显示出出色的分析性能，可用于测定ST。此外，还获得了出色的抗干扰能力，并在存在其他化合物（如抗坏血酸，多巴胺和抗抑郁药）的同时测定了ST。

更新日期：2018-03-30

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