An efficient and environmentally friendly catalytic route for the reductive amination of carbonyl compounds has been designed. First, a one-pot procedure has been followed for the synthesis and incorporation of gold nanoparticles (AuNPs) into a mesoporous silica solid by using light as an abundant and clean energy source. Then, the as-prepared material has been successfully employed as a heterogeneous catalyst in the production of secondary and tertiary amines by reductive amination using Ph(Me)₂SiH as the reducing agent. The endurance of the catalyst has been demonstrated in batch, and a continuous flow process allowing the safe preparation of multigram amounts of reductive amination products (accumulated TON = 434 in 18 h operation involving 6 sequential examples) has been implemented. The scope of the reaction has also been extended to the synthesis of more challenging active pharmaceutical ingredients (APIs), such as indoprofen precursors and biomass-derived products, which were obtained in good to excellent yields.

中文翻译：

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多功能，固定化的金催化剂，用于批量和连续还原醛的胺化†

设计了一种有效的和环境友好的催化途径，用于羰基化合物的还原胺化。首先，通过使用一锅法将金纳米颗粒（AuNPs）合成并通过使用光作为丰富而清洁的能源将其掺入介孔二氧化硅固体中。然后，所制备的材料已成功地用作非均相催化剂，通过使用Ph（Me）₂进行还原胺化来生产仲胺和叔胺SiH作为还原剂。已分批证明了催化剂的耐久性，并且已实施了允许安全制备数克量的还原性胺化产物的连续流工艺（在18个小时的操作中，累积的TON = 434，涉及6个连续的实例）。该反应的范围也已扩展到合成更具挑战性的活性药物成分（API），例如吲哚洛芬前体和生物质衍生的产品，它们的收率高到极好。