Abstract

The three-component reaction of triphenylphosphine, dimethyl acetylenedicarboxylate and 3-arylamino-1-methyl-1H-pyrrole-2,5-diones in CH₂Cl₂ at room temperature resulted in functionalized 3-(triphenyl-λ⁵-phosphanylidene)succinates in nearly quantitative yields. However, tri(n-butyl)phosphine promoted reaction of dialkyl acetylenedicarboxylates and 3-arylamino-1-methyl-1H-pyrrole-2,5-diones in CH₂Cl₂ afforded functionalized pyrrolo[3,4-b]pyridine-4-carboxylates in satisfactory yields.

The three-component reaction of triphenylphosphine, dimethyl acetylenedicarboxylate and 3-arylamino-1-methyl-1H-pyrrole-2,5-diones in CH₂Cl₂ at room temperature resulted in functionalized 3-(triphenyl-λ⁵-phosphanylidene)succinates in nearly quantitative yields. However, tri(n-butyl)phosphine promoted reaction of dialkyl acetylenedicarboxylates and 3-arylamino-1-methyl-1H-pyrrole-2,5-diones in CH₂Cl₂ afforded functionalized pyrrolo[3,4-b]pyridine-4-carboxylates in satisfactory yields.

中文翻译：

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乙二酸二烷基酯与3-芳基氨基-1-甲基-1H-吡咯-2,5-二酮的亲核膦促进多米诺反应

摘要

三苯基膦的三组分反应，乙炔二和三芳基氨基-1-甲基- 1 H ^ -吡咯-2,5-二酮在CH ₂氯₂在室温下导致官能3-（三苯基-λ ⁵ -phosphanylidene）琥珀酸酯的收率接近定量。然而，三（正丁基）膦在CH ₂ Cl _2中促进了乙炔二羧酸二烷基酯与3-芳基氨基-1-甲基-1 H-吡咯-2,5-二酮的反应，提供了官能化的吡咯并[3,4- b ]吡啶- 4-羧酸盐具有令人满意的产率。

三苯基膦的三组分反应，乙炔二和三芳基氨基-1-甲基- 1 H ^ -吡咯-2,5-二酮在CH ₂氯₂在室温下导致官能3-（三苯基-λ ⁵ -phosphanylidene）琥珀酸酯的收率接近定量。然而，三（正丁基）膦在CH ₂ Cl _2中促进了乙炔二羧酸二烷基酯与3-芳基氨基-1-甲基-1 H-吡咯-2,5-二酮的反应，提供了官能化的吡咯并[3,4- b ]吡啶- 4-羧酸盐具有令人满意的产率。