Red Blood Cell-Shaped Microparticles with a Red Blood Cell Membrane Demonstrate Prolonged Circulation Time in Blood,ACS Biomaterials Science & Engineering

当前位置： X-MOL 学术 › ACS Biomater. Sci. Eng. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Red Blood Cell-Shaped Microparticles with a Red Blood Cell Membrane Demonstrate Prolonged Circulation Time in Blood
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-07-13 00:00:00 , DOI: 10.1021/acsbiomaterials.8b00197
Koichiro Hayashi _{1,

2} , Shota Yamada ₁ , Wataru Sakamoto ₁ , Eri Usugi ₃ , Masatoshi Watanabe ₃ , Toshinobu Yogo ₁

Affiliation

Prolonging the circulation time (CT) of microparticles (MPs) in the blood is key for a successful microparticle-based medicinal approach to serve as drug delivery systems (DDSs). Previously, we reported that MPs that mimic the shape of red blood cells (RBCs) avoid accumulation in the spleen and lungs. We now describe the effectiveness of mimicking not only the shape of RBCs but also their surface structure for the prolongation of CT. RBC-shaped MPs (RBC-MPs) were electrosprayed with cellulose and covered with a native RBC membrane (RBCM) collected from mouse blood. Seven hours after intravenous injection, approximately twice as many RBCM-covered RBC-MPs ([email protected]) were present in the blood of mice compared to unmodified RBC-MPs. Twenty-four hours postinjection, the concentration of [email protected] in the blood was 4 times higher. These findings suggest that an RBCM covering the MPs contributed to significant CT prolongation, which may positively impact their applications as DDSs.

中文翻译：

具有红细胞膜的红细胞形状微粒显示血液中延长的循环时间

延长血液中微粒（MP）的循环时间（CT）是成功用作药物输送系统（DDS）的基于微粒的医学方法的关键。先前，我们报道了模仿红细胞（RBC）形状的MP避免在脾脏和肺部积聚。现在，我们描述了不仅模仿RBC的形状而且模仿其表面结构对于延长CT的有效性。用纤维素对RBC形MP（RBC-MP）进行电喷雾，并用从小鼠血液中收集的天然RBC膜（RBCM）覆盖。静脉注射后七个小时，与未经修饰的RBC-MP相比，小鼠血液中存在大约两倍于RBCM覆盖的RBC-MP（[电子邮件保护]）。注射后二十四小时，血液中[被保护的电子邮件]的浓度高出四倍。

更新日期：2018-07-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11