C–H Monoarylation of Naphthylpyrimidines with Aryl Chlorides Catalyzed by a Water-Soluble Ruthenium Complex,Synlett

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C–H Monoarylation of Naphthylpyrimidines with Aryl Chlorides Catalyzed by a Water-Soluble Ruthenium Complex
Synlett ( IF 1.7 ) Pub Date : 2018-07-10 , DOI: 10.1055/s-0037-1610457
Zhi-Qiang Wang ₁ , Xin-Qi Hao ₂ , Chen Xu _{1,

3} , Hong-Mei Li ₁ , Tian-Yong Tu ₂ , Xin Han ₂ , Wei-Jun Fu ₁ , Mao-Ping Song ₂

Affiliation

Selective monoarylation of naphthylpyrimidines with a variety of aryl chlorides through C–H bond activation in water was achieved by using a water-soluble [RuCl2-(η6-PhOCH2CH2OH)]2/phosphine catalytic system. The monoarylation occurred at the C-2 carbon of the naphthalene moiety, and selectively polysubstituted naphthylpyrimidines were obtained by a one-pot reaction involving a subsequent hetarylation with 2-pyridyl chlorides.

中文翻译：

水溶性钌配合物催化萘基嘧啶与芳基氯化物的 C-H 单芳基化反应

通过使用水溶性 [RuCl2-(η6-PhOCH2CH2OH)]2/膦催化体系，通过在水中的 C-H 键活化，萘基嘧啶与各种芳基氯的选择性单芳基化实现了。单芳基化发生在萘部分的 C-2 碳上，选择性多取代的萘基嘧啶通过一锅反应获得，包括随后与 2-吡啶基氯的杂芳基化。

更新日期：2018-07-10

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