Biomimetic Tissue Engineering: Tuning the Immune and Inflammatory Response to Implantable Biomaterials,Advanced Healthcare Materials

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Biomimetic Tissue Engineering: Tuning the Immune and Inflammatory Response to Implantable Biomaterials
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-07-11 , DOI: 10.1002/adhm.201800490
Francesca Taraballi _{1,

2} , Manuela Sushnitha _{1,

3} , Christopher Tsao ₁ , Guillermo Bauza _{1,

4} , Chiara Liverani _{1,

5} , Aaron Shi _{1,

6} , Ennio Tasciotti _{1,

2}

Affiliation

Regenerative medicine technologies rely heavily on the use of well‐designed biomaterials for therapeutic applications. The success of implantable biomaterials hinges upon the ability of the chosen biomaterial to negotiate with the biological barriers in vivo. The most significant of these barriers is the immune system, which is composed of a highly coordinated organization of cells that induce an inflammatory response to the implanted biomaterial. Biomimetic platforms have emerged as novel strategies that aim to use the principle of biomimicry as a means of immunomodulation. This principle has manifested itself in the form of biomimetic scaffolds that imitate the composition and structure of biological cells and tissues. Recent work in this area has demonstrated the promising potential these technologies hold in overcoming the barrier of the immune system and, thereby, improve their overall therapeutic efficacy. In this review, a broad overview of the use of these strategies across several diseases and future avenues of research utilizing these platforms is provided.

中文翻译：

仿生组织工程：调整对植入式生物材料的免疫和炎症反应。

再生医学技术在很大程度上依赖于将经过精心设计的生物材料用于治疗应用。植入式生物材料的成功取决于所选择的生物材料与体内生物屏障进行协商的能力。这些障碍中最重要的是免疫系统，它是由高度协调的细胞组织组成的，该组织诱导对植入的生物材料的炎症反应。仿生平台已经作为旨在将仿生原理用作免疫调节手段的新策略而出现。该原理以仿生支架的形式表现出来，其模仿了生物细胞和组织的组成和结构。在该领域的最新工作表明，这些技术在克服免疫系统的障碍，从而提高其整体治疗功效方面具有广阔的潜力。在这篇综述中，提供了在多种疾病中使用这些策略的广泛概述，以及利用这些平台的未来研究途径。

更新日期：2018-07-11

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