Selective Epoxidation of Fatty Acids and Fatty Acid Methyl Esters by Fungal Peroxygenases,ChemCatChem

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Selective Epoxidation of Fatty Acids and Fatty Acid Methyl Esters by Fungal Peroxygenases
ChemCatChem ( IF 3.8 ) Pub Date : 2018-07-26 , DOI: 10.1002/cctc.201800849
Carmen Aranda ₁ , Andrés Olmedo ₁ , Jan Kiebist ₂ , Katrin Scheibner ₂ , José C. del Río ₁ , Angel T. Martínez ₃ , Ana Gutiérrez ₁

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Recently discovered fungal unspecific peroxygenases from Marasmius rotula and Chaetomium globosum catalyze the epoxidation of unsaturated fatty acids (FA) and FA methyl esters (FAME), unlike the well‐known peroxygenases from Agrocybe aegerita and Coprinopsis cinerea. Reactions of a series of unsaturated FA and FAME with cis‐configuration revealed high (up to 100 %) substrate conversion and selectivity towards epoxidation, although some significant differences were observed between enzymes and substrates with the best results being obtained with the C. globosum enzyme. This and the M. rotula peroxygenase appear as promising biocatalysts for the environmentally‐friendly production of reactive FA epoxides given their self‐sufficient monooxygenase activity and the high conversion rate and epoxidation selectivity.

中文翻译：

真菌过氧合酶对脂肪酸和脂肪酸甲酯的选择性环氧化

最近发现，来自轮藻（Marasmius rotula）和球毛壳壳（Chaetomium globosum）的真菌非特异性过氧化酶催化不饱和脂肪酸（FA）和FA甲基酯（FAME）的环氧化，这与著名的农杆菌（Agrocybe aegerita）和灰霉菌（Coprinopsis cinerea）的过氧化酶不同。一系列不饱和FA和FAME与的反应顺式-构型显示高（高达100％）的底物转化并朝向环氧化的选择性，尽管进行了酶和底物的最佳结果之间观察到一些差异显著与所述获得的球毛壳菌酶。这和罗氏沼虾 过氧合酶具有自给自足的单加氧酶活性，高转化率和环氧化选择性，因此有望成为环保生产反应性FA环氧化物的有前途的生物催化剂。

更新日期：2018-07-26

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