The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 on natural killer (NK) cell activity, cytokines and immunoglobulins (Igs). This randomized, double-blinded, placebo-controlled study enrolled 100 nondiabetic participants. For eight weeks, the probiotic group consumed capsules containing 1 × 10¹⁰ colony forming units (cfu) of W. cibaria JW15 daily, whereas the placebo group consumed the same capsules without a probiotic. NK cell activity at effector cell (E; peripheral blood mononuclear cells, PBMCs):target cell (T; K562 cells) ratios of 10:1, 5:1, 2.5:1, or 1.25:1 was significantly increased in the probiotic group compared to the placebo group at 8 weeks after baseline. The probiotic group had significantly greater increases in NK cell activity than the placebo group under all assay conditions. Daily consumption of the W. cibaria JW15 probiotic effectively enhanced immune functions by increasing NK cell activity (Clinicaltrials.gov; NCT03209635).

这项研究的目的是调查食用Weissella cibaria（W. cibaria）JW15对自然杀伤（NK）细胞活性，细胞因子和免疫球蛋白（Igs）的影响。这项随机，双盲，安慰剂对照的研究招募了100名非糖尿病参与者。八周中，益生菌组食用了含有1×10 ^10个西班氏菌菌落形成单位（cfu）的胶囊每天JW15，而安慰剂组则服用相同的胶囊而没有益生菌。益生菌组中效应细胞（E；外周血单核细胞，PBMC）：靶细胞（T； K562细胞）的NK细胞活性以10：1、5：1、2.5：1或1.25：1的比例显着增加与基线后8周的安慰剂组比较。在所有试验条件下，益生菌组的NK细胞活性增加量均明显高于安慰剂组。每日食用的W. cibaria JW15益生菌可通过增加NK细胞活性来有效增强免疫功能（Clinicaltrials.gov； NCT03209635）。