Background

The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years from stroke attributable to exposure to long working hours, to inform the development of the WHO/ILO joint methodology.

Objectives

We aim to systematically review studies on occupational exposure to long working hours (called Systematic Review 1 in the protocol) and systematically review and meta-analyse estimates of the effect of long working hours on stroke (called Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework, conducting both systematic reviews in tandem and in a harmonized way.

Data sources

Separately for Systematic Reviews 1 and 2, we will search electronic academic databases for potentially relevant records from published and unpublished studies, including Medline, EMBASE, Web of Science, CISDOC and PsychINFO. We will also search electronic grey literature databases, Internet search engines and organizational websites; hand-search reference list of previous systematic reviews and included study records; and consult additional experts.

Study eligibility and criteria

We will include working-age (≥15 years) workers in the formal and informal economy in any WHO and/or ILO Member State, but exclude children (<15 years) and unpaid domestic workers. For Systematic Review 1, we will include quantitative prevalence studies of relevant levels of occupational exposure to long working hours (i.e. 35–40, 41–48, 49–54 and ≥55 h/week) stratified by country, sex, age and industrial sector or occupation, in the years 2005–2018. For Systematic Review 2, we will include randomized controlled trials, cohort studies, case-control studies and other non-randomized intervention studies with an estimate of the relative effect of a relevant level of long working hours on the incidence of or mortality due to stroke, compared with the theoretical minimum risk exposure level (i.e. 35–40 h/week).

Study appraisal and synthesis methods

At least two review authors will independently screen titles and abstracts against the eligibility criteria at a first stage and full texts of potentially eligible records at a second stage, followed by extraction of data from qualifying studies. At least two review authors will assess risk of bias and the quality of evidence, using the most suited tools currently available. For Systematic Review 2, if feasible, we will combine relative risks using meta-analysis. We will report results using the guidelines for accurate and transparent health estimates reporting (GATHER) for Systematic Review 1 and the preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA) for Systematic Review 2.

PROSPERO registration number: CRD42017060124.

中文翻译：

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世卫组织/国际劳工组织与工作相关的疾病和伤害负担：长期工作时间暴露和长期工作时间暴露对中风影响的系统评价方案

背景

世界卫生组织 (WHO) 和国际劳工组织 (ILO) 正在开发一种联合方法，用于估计国家和全球与工作相关的疾病和伤害负担（WHO/ILO 联合方法），该方法来自大型专家网络. 在本文中，我们提出了两项​​系统评价参数的方案，以估计因长时间工作而导致的中风死亡人数和残疾调整生命年，为 WHO/ILO 联合方法的发展提供信息。

目标

我们的目标是系统地审查关于长时间工作的职业暴露的研究（在方案中称为系统审查 1），并系统审查和荟萃分析对长时间工作对卒中影响的估计（称为系统审查 2），应用导航指南系统评价方法作为一个组织框架，以协调一致的方式进行系统评价。

数据源

对于系统评价 1 和 2，我们将分别在电子学术数据库中搜索已发表和未发表研究的潜在相关记录，包括 Medline、EMBASE、Web of Science、CISDOC 和 PsychINFO。我们还将搜索电子灰色文献数据库、互联网搜索引擎和组织网站；手动搜索以前系统评价的参考列表和包含的研究记录；并咨询其他专家。

研究资格和标准

我们将包括任何世卫组织和/或国际劳工组织成员国的正规和非正规经济中的工作年龄（≥15 岁）工人，但不包括儿童（<15 岁）和无薪家庭工人。对于系统评价 1，我们将包括按国家、性别、年龄和行业分层的长期工作时间（即 35-40、41-48、49-54 和 ≥55 小时/周）的相关职业暴露水平的定量流行率研究部门或职业，2005-2018 年。对于系统评价 2，我们将纳入随机对照试验、队列研究、病例对照研究和其他非随机干预研究，以估计相关水平的长时间工作对中风发病率或死亡率的相对影响，与理论最低风险暴露水平（即 35-40 小时/周）相比。

研究评价与综合方法

至少有两名综述作者将在第一阶段根据资格标准独立筛选标题和摘要，在第二阶段独立筛选可能符合条件的记录的全文，然后从符合条件的研究中提取数据。至少有两名综述作者将使用目前可用的最合适的工具评估偏倚风险和证据质量。对于系统评价 2，如果可行，我们将使用荟萃分析结合相对风险。我们将使用系统评价 1 的准确和透明的健康估计报告指南 (GATHER) 和系统评价 2 的系统评价和荟萃分析指南 (PRISMA) 的首选报告项目报告结果。

PROSPERO 注册号：CRD42017060124。