Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2.,ACS Chemical Neuroscience

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Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-07-19 , DOI: 10.1021/acschemneuro.8b00290
Yanan Hou ₁ , Shoujiao Peng ₁ , Xinming Li ₁ , Juan Yao ₁ , Jianqiang Xu ₂ , Jianguo Fang ₁

Affiliation

Honokiol (Hon), a polyphenol and main active ingredient from the bark of Magnolia officinalis, has been documented as having multiple pharmacological functions, including neuroprotection. However, the mechanisms underlying its neuroprotective effects are not well-defined. In this study, we reported that Hon attenuates the H2O2- or 6-hydroxydopamine (6-OHDA)-induced apoptosis of PC12 cells by increasing the glutathione level and upregulating a multitude of cytoprotective proteins, including heme oxygenase 1, NAD(P)H:quinone oxidoreductase 1, thioredoxin 1, and thioredoxin reductase 1. Further studies reveal that Hon promotes transcription factor Nrf2 nuclear translocation and activation. Moreover, the cytoprotection of Hon was antagonized by silence of Nrf2 expression, highlighting the fact that Nrf2 is critically engaged in the cellular functions of Hon. Taken together, our study identified that Hon is an effective agonist of Nrf2 in the neuronal system and displays potent neuroprotection against oxidative stress-mediated PC12 cell damage. These findings indicate that Hon is promising for further development as a therapeutic drug against oxidative stress-related neurodegenerative disorders.

中文翻译：

厚朴酚通过激活Nrf2减轻氧化应激诱导的神经毒性。

厚朴酚（厚朴酚）是多酚和木兰皮的主要活性成分，已被证明具有多种药理功能，包括神经保护作用。但是，其神经保护作用的潜在机制尚不清楚。在这项研究中，我们报道了Hon通过增加谷胱甘肽水平和上调多种细胞保护性蛋白（包括血红素加氧酶1，NAD（P）H）来减轻H2O2-或6-羟基多巴胺（6-OHDA）诱导的PC12细胞凋亡。：醌氧化还原酶1，硫氧还蛋白1和硫氧还蛋白还原酶1。进一步的研究表明Hon可以促进转录因子Nrf2的核转运和激活。此外，Nrf2表达的沉默使Hon的细胞保护作用被拮抗，强调了Nrf2关键参与Hon的细胞功能这一事实。两者合计，我们的研究确定Hon是Nrf2在神经元系统中的有效激动剂，并显示出对氧化应激介导的PC12细胞损伤的有效神经保护作用。这些发现表明，Hon有望作为抗氧化应激相关神经退行性疾病的治疗药物而进一步发展。

更新日期：2018-07-10

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