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Wettability Study on Natural Rubber Surfaces for Applications as Biomembranes
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-07-10 00:00:00 , DOI: 10.1021/acsbiomaterials.8b00723 Rodney Marcelo do Nascimento 1 , Stella M. M. Ramos 2 , Ivan Helmuth Bechtold 3 , Antônio Carlos Hernandes 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-07-10 00:00:00 , DOI: 10.1021/acsbiomaterials.8b00723 Rodney Marcelo do Nascimento 1 , Stella M. M. Ramos 2 , Ivan Helmuth Bechtold 3 , Antônio Carlos Hernandes 1
Affiliation
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This manuscript reports an experimental study on surfaces of natural rubber membranes modified by incorporation of calcium phosphate particles. In particular, we focused on the wettability, a subject for biological aspects. Five surfaces of natural rubber (NR) membranes (pure, polymer-bioceramic composite (NR-CaP), and three modified surfaces subjected to a simulated body fluid (NR-SBF)) were produced and characterized by confocal Raman-spectroscopy, AFM, SEM, and XPS, and the results were correlated with the wetting properties. Seven liquids (water, formamide, di-iodomethane, ethylene glycol, hexadecane, simulated body fluid, and human blood droplets) were used in different experimental sections. Static and dynamic contact angle measurements were conducted to obtain the solid–liquid tensions, work of adhesion, and depinning forces. The incorporation of CaP particles in the polymer decreases the roughness and increases the interfacial adhesion, and there was no dependence between the morphology and equilibrium contact line. The hydrophobic state of the NR surfaces is preserved. After exposure to a biological environment, the NR surfaces were chemically modified increasing blood wettability and decreasing the negative surface charges and the contact angle to values close to those associated with protein adsorption and cell adhesion, therefore opening possibilities for applications of these materials as biomembranes. On the other hand, the concepts applied, regarding different wettability aspects, should enable the evaluation of biomaterial surfaces and provide new insights allowing a better understanding of body fluid–material interfaces.
中文翻译：
天然橡胶表面用作生物膜的润湿性研究
该手稿报道了对通过掺入磷酸钙颗粒改性的天然橡胶膜表面的实验研究。特别是，我们专注于润湿性，这是生物学方面的主题。通过共聚焦拉曼光谱（AFM）制备并表征了天然橡胶（NR）膜的五个表面（纯净的聚合物-生物陶瓷复合材料（NR-CaP）和三个经过改性的表面经过模拟的体液（NR-SBF））。 SEM和XPS，结果与润湿性能相关。在不同的实验区域中使用了七种液体（水，甲酰胺，二碘甲烷，乙二醇，十六烷，模拟体液和人体液滴）。进行了静态和动态接触角测量，以获得固液张力，附着力和固定力。CaP颗粒在聚合物中的掺入降低了粗糙度并增加了界面粘合力，并且形态和平衡接触线之间没有依赖性。NR表面的疏水状态得以保留。暴露于生物环境后，对NR表面进行了化学修饰，从而提高了血液的润湿性，并将负表面电荷和接触角减小到接近与蛋白质吸附和细胞粘附相关的值，因此为这些材料作为生物膜的应用开辟了可能性。另一方面，所应用的概念涉及不同的润湿性方面，应该能够评估生物材料的表面并提供新的见解，从而可以更好地理解体液-材料的界面。
更新日期：2018-07-10
中文翻译：
天然橡胶表面用作生物膜的润湿性研究
该手稿报道了对通过掺入磷酸钙颗粒改性的天然橡胶膜表面的实验研究。特别是，我们专注于润湿性，这是生物学方面的主题。通过共聚焦拉曼光谱（AFM）制备并表征了天然橡胶（NR）膜的五个表面（纯净的聚合物-生物陶瓷复合材料（NR-CaP）和三个经过改性的表面经过模拟的体液（NR-SBF））。 SEM和XPS，结果与润湿性能相关。在不同的实验区域中使用了七种液体（水，甲酰胺，二碘甲烷，乙二醇，十六烷，模拟体液和人体液滴）。进行了静态和动态接触角测量，以获得固液张力，附着力和固定力。CaP颗粒在聚合物中的掺入降低了粗糙度并增加了界面粘合力，并且形态和平衡接触线之间没有依赖性。NR表面的疏水状态得以保留。暴露于生物环境后，对NR表面进行了化学修饰，从而提高了血液的润湿性，并将负表面电荷和接触角减小到接近与蛋白质吸附和细胞粘附相关的值，因此为这些材料作为生物膜的应用开辟了可能性。另一方面，所应用的概念涉及不同的润湿性方面，应该能够评估生物材料的表面并提供新的见解，从而可以更好地理解体液-材料的界面。
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