An organocatalytic asymmetric Mannich reaction for the synthesis of 3,3-disubstituted-3,4-dihydro-2-quinolones†,Organic & Biomolecular Chemistry

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An organocatalytic asymmetric Mannich reaction for the synthesis of 3,3-disubstituted-3,4-dihydro-2-quinolones†
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-07-11 00:00:00 , DOI: 10.1039/c8ob01399c
Soumendranath Mukhopadhyay _{1,

2,

3} , Subhas Chandra Pan _{1,

2,

3}

Affiliation

The first organocatalytic asymmetric Mannich reaction employing 3,4-dihydro-2-quinolones has been developed for the synthesis of biologically important 3,3-disubstituted-dihydro-2-quinolones. N-Boc imine precursor amidosulfones as well as pre-formed N-Boc imine were used for this purpose. Cyclohexyldiamine derived bifunctional amino-thiourea catalysts were employed to provide the products in high enantio- and good diastereoselectivities.

中文翻译：

有机催化不对称曼尼希反应，用于合成3,3-二取代-3,4-二氢-2-喹诺酮†

已经开发了使用3，4-二氢-2-喹诺酮的第一个有机催化不对称曼尼希反应，用于合成生物学上重要的3，3-二取代-二氢-2-喹诺酮。N- Boc亚胺前体酰胺砜以及预先形成的N - Boc亚胺均用于此目的。使用环己基二胺衍生的双官能氨基-硫脲催化剂可提供高对映异构性和良好的非对映选择性的产物。

更新日期：2018-07-11

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