Recent advances in the application of Diels–Alder reactions involving o-quinodimethanes, aza-o-quinone methides and o-quinone methides in natural product total synthesis,Chemical Society Reviews

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Recent advances in the application of Diels–Alder reactions involving o-quinodimethanes, aza-o-quinone methides and o-quinone methides in natural product total synthesis
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-07-11 00:00:00 , DOI: 10.1039/c8cs00274f
Baochao Yang _{1,

2,

3,

4,

5} , Shuanhu Gao _{1,

2,

3,

4,

5}

Affiliation

In recent decades, transient and highly reactive ortho-quinodimethanes (o-QDMs), ortho-quinone methides (o-QMs) and aza-ortho-quinone methides (aza-o-QMs) have attracted much attention and have been extensively studied and applied in organic synthesis, especially natural product total synthesis. This review summarizes recent advances in Diels–Alder reactions involving in situ-generated o-QDMs, o-QMs and aza-o-QMs, highlighting the power and potential of this strategy in organic synthesis and natural product total synthesis. An overview of the methods for generating these intermediates is also available.

中文翻译：

涉及邻喹二甲烷，氮杂邻醌醌和邻醌甲基醚的狄尔斯-阿尔德反应在天然产物全合成中应用的最新进展

在最近的几十年中，瞬态和高反应性的邻苯二甲甲烷（o -QDMs），邻苯二甲酮甲基化物（o -QMs）和氮杂-邻苯醌甲基化物（aza- o -QMs）引起了广泛的关注，并得到了广泛的研究。用于有机合成，特别是天然产物的全合成。本文总结的Diels-Alder反应涉及的最新进展原位-生成Ø -QDMs，ø -QMs和氮杂Ø-QM，突出了该策略在有机合成和天然产物全合成中的作用和潜力。还提供了有关生成这些中间体的方法的概述。

更新日期：2018-07-11

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