Noninvasive real-time monitoring of local drug release using nano-Au-absorbed self-decomposable SiO2 carriers†,Nanoscale

当前位置： X-MOL 学术 › Nanoscale › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Noninvasive real-time monitoring of local drug release using nano-Au-absorbed self-decomposable SiO2 carriers†
Nanoscale ( IF 5.8 ) Pub Date : 2018-07-12 00:00:00 , DOI: 10.1039/c8nr03782e
Li Fan _{1,

2,

3,

4,

5} , Jingnan Yang _{6,

7,

8,

9} , Ken Cham-Fai Leung _{9,

10,

11,

12} , Chaojun Song _{4,

5,

13,

14} , Quan Li _{6,

7,

8,

9}

Affiliation

Real time monitoring of drug release at specific local sites by a non-invasive imaging method is critical in patient-specific drug administration in order to avoid insufficient or excess drug dosing. In the present work, we designed a specific carrier system for such a purpose using self-decomposable SiO₂ nanoparticles (NPs) with the drug being loaded in the center and Au NPs on the SiO₂ NPs as the imaging agent. We discovered a correlation between the drug release from the carrier and the morphological evolution of Au NPs, which also left the carrier and changed their aggregation states along with the drug release process. This finding enabled the real time monitoring of the drug release at local sites (e.g. tumor) in a quantitative manner by recording the CT signal evolution of the Au NPs, as demonstrated in vivo using mice bearing Colo-205 xenografts. The present work provided a promising platform for non-invasive real time tracking on the localized drug release, enabling a variety of personalized therapeutic applications.

中文翻译：

使用纳米金吸收的自分解SiO ₂载体对局部药物释放进行无创实时监测†

为了避免药物剂量不足或过量，通过非侵入性成像方法实时监测特定部位的药物释放对于患者特定的药物管理至关重要。在目前的工作中，我们设计了一种特殊的载体系统，使用可自行分解的SiO ₂纳米颗粒（NPs），其中药物负载在中心，而SiO ₂ NPs上的Au NPs作为显像剂。我们发现从载体释放的药物与Au NPs的形态演变之间存在相关性，Au NPs也离开了载体并随着药物释放过程而改变了它们的聚集状态。这一发现使得能够实时监控本地场所的药物释放情况（例如，肿瘤）），通过记录Au NP的CT信号演变以定量方式进行，如使用带有Colo-205异种移植物的小鼠体内证实的那样。目前的工作为局部药物释放的非侵入性实时跟踪提供了一个有希望的平台，使各种个性化治疗应用成为可能。

更新日期：2018-07-12

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11