UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids†,Chemical Communications

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UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-07-11 00:00:00 , DOI: 10.1039/c8cc04215b
Junbin He _{1,

2,

3,

4,

5} , Kuan Chen _{1,

2,

3,

4,

5} , Zhi-min Hu _{1,

2,

3,

4,

5} , Kai Li _{1,

2,

3,

4,

5} , Wei Song _{1,

2,

3,

4,

5} , Li-yan Yu _{5,

6,

7,

8} , Chung-Hang Leung _{5,

9,

10,

11,

12} , Dik-Lung Ma _{5,

13,

14,

15} , Xue Qiao _{1,

2,

3,

4,

5} , Min Ye _{1,

2,

3,

4,

5}

Affiliation

State Key Laboratory of Natural and Biomimetic Drugs
School of Pharmaceutical Sciences
Peking University
Beijing 100191
China
Institute of Medicinal Biotechnology
Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing 100050
State Key Laboratory of Quality Research in Chinese Medicine
Institute of Chinese Medical Sciences
University of Macau
Macau
Department of Chemistry
Hong Kong Baptist University
Kowloon Tong

The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

中文翻译：

UGT73F17，一种来自甘草的新糖基转移酶，催化五环三萜类化合物的区域特异性糖基化作用†

突出了UGT73F17（一种来自甘草的新糖基转移酶）对五环三萜类化合物的区域特异性糖基化作用。UGT73F17对五环三萜类化合物的C-30 / C-29处的羧基表现出严格的底物特异性，并与糖供体高度混杂。UGT73F17代表第一个鉴定出的三萜类30 / 29- O-糖基转移酶，可以用作合成糖基酯皂苷的有效生物催化剂。

更新日期：2018-07-11

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