Supramolecular nanoparticles based on β-CD modified hyaluronic acid for DNA encapsulation and controlled release†,Chemical Communications

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Supramolecular nanoparticles based on β-CD modified hyaluronic acid for DNA encapsulation and controlled release†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-07-10 00:00:00 , DOI: 10.1039/c8cc04783a
Yang Yang _{1,

2,

3,

4} , Xin Jia _{1,

2,

3,

4} , Ying-Ming Zhang _{3,

4,

5,

6,

7} , Nan Li _{3,

4,

8,

9} , Yu Liu _{3,

4,

5,

6,

7}

Affiliation

Supramolecular nanoparticles composed of doubly positively charged adamantane (ADA2+) and β-CD modified hyaluronic acid (HACD) were constructed. When the ester group in ADA2+ was hydrolyzed to a carboxyl group, the quaternary ammonium chain with a positive charge in ADA2+ converted to a “zwitterionic” structure, and the controlled binding and release of pDNA was realized.

中文翻译：

基于β-CD修饰的透明质酸的超分子纳米颗粒，用于DNA包封和控释†

构造了由双正电荷的金刚烷（ADA2 +）和β-CD修饰的透明质酸（HACD）组成的超分子纳米颗粒。当ADA2 +中的酯基水解为羧基时，ADA2 +中带有正电荷的季铵链转变为“两性离子”结构，从而实现了pDNA的受控结合和释放。

更新日期：2018-07-10

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