Radical-mediated direct C–H amination of arenes with secondary amines†,Chemical Science

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Radical-mediated direct C–H amination of arenes with secondary amines†
Chemical Science ( IF 7.6 ) Pub Date : 2018-07-11 00:00:00 , DOI: 10.1039/c8sc01747f
Sebastian C. Cosgrove _{1,

2,

3,

4} , John M. C. Plane _{1,

2,

3,

4} , Stephen P. Marsden _{1,

2,

3,

4}

Affiliation

Aryl dialkyl amines, valuable subunits of a wide range of effect chemicals, are accessed by intramolecular amination of aromatic C–H bonds employing UV photolysis of N-chloroamines. The reactions show good functional group tolerance and allow access to a range of fused and bridged polycyclic structures. The homogeneous reaction conditions allow for the one-pot conversion of secondary amines to their arylated derivatives. Experimental and theoretical evidence supports the involvement of electrophilic aminium radicals which react via direct ortho-attack on the arene.

中文翻译：

自由基介导的芳烃与仲胺的直接C–H胺化†

芳基二烷基胺是广泛的作用化学物质的重要亚基，可通过使用N-氯胺的UV光解，通过芳族CH键的分子内胺化作用来获得。反应显示出良好的官能团耐受性，并允许进入一系列稠合和桥连的多环结构。均相反应条件允许将一元胺一锅转化为它们的芳基化衍生物。实验和理论证据支持亲电性铝自由基的参与，所述亲电性铝自由基通过直接邻位攻击在芳烃上反应。

更新日期：2018-07-11

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