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Monitoring the Opening and Recovery of the Blood–Brain Barrier with Noninvasive Molecular Imaging by Biodegradable Ultrasmall Cu2–xSe Nanoparticles
Nano Letters ( IF 9.6 ) Pub Date : 2018-07-11 00:00:00 , DOI: 10.1021/acs.nanolett.8b01818 Hao Zhang 1 , Tingting Wang 1 , Weibao Qiu 2 , Yaobao Han 1 , Qiao Sun 1 , Jianfeng Zeng 1 , Fei Yan 2 , Hairong Zheng 2 , Zhen Li 1 , Mingyuan Gao 1
Nano Letters ( IF 9.6 ) Pub Date : 2018-07-11 00:00:00 , DOI: 10.1021/acs.nanolett.8b01818 Hao Zhang 1 , Tingting Wang 1 , Weibao Qiu 2 , Yaobao Han 1 , Qiao Sun 1 , Jianfeng Zeng 1 , Fei Yan 2 , Hairong Zheng 2 , Zhen Li 1 , Mingyuan Gao 1
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The reversible and controllable opening and recovery of the blood–brain barrier (BBB) is crucial for the treatment of brain diseases, and it is a big challenge to noninvasively monitor these processes. In this article, dual-modal photoacoustic imaging and single-photon-emission computed tomography imaging based on ultrasmall Cu2–xSe nanoparticles (3.0 nm) were used to noninvasively monitor the opening and recovery of the BBB induced by focused ultrasound in living mice. The ultrasmall Cu2–xSe nanoparticles were modified with poly(ethylene glycol) to exhibit a long blood circulation time. Both small size and long blood circulation time enable them to efficiently penetrate into the brain with the assistance of ultrasound, which resulted in a strong signal at the sonicated site and allowed for photoacoustic and single-photon emission computed tomography imaging monitoring the recovery of the opened BBB. The results of biodistribution, blood routine examination, and histological staining indicate that the accumulated Cu2–xSe nanoparticles could be excreted from the brain and other major organs after 15 days without causing side effects. By the combination of the advantages of noninvasive molecular imaging and focused ultrasound, the ultrasmall biocompatible Cu2–xSe nanoparticles holds great potential for the diagnosis and therapeutic treatment of brain diseases.
中文翻译：
通过可生物降解的超小Cu 2– x Se纳米粒子的无创分子成像监测血脑屏障的开放和恢复
血脑屏障（BBB）的可逆和可控制的开放和恢复对于脑疾病的治疗至关重要，并且以无创方式监测这些过程也是一个巨大的挑战。在本文中，基于超小Cu 2– x Se纳米粒子（3.0 nm）的双模态光声成像和单光子发射计算机断层摄影成像被用于无创地监测活体小鼠聚焦超声诱导的血脑屏障的开放和恢复。 。超小型Cu 2 – x硒纳米颗粒用聚乙二醇改性，表现出较长的血液循环时间。体积小和血液循环时间长，使它们能够在超声的帮助下有效地渗透到大脑中，从而在声处理的部位产生强信号，并允许进行光声和单光子发射计算机断层摄影成像，以监测打开后的恢复情况BBB。生物分布，血液常规检查和组织学染色的结果表明，累积的Cu 2– x Se纳米粒子可以在15天后从大脑和其他主要器官排出，而不会引起副作用。结合无创分子成像和聚焦超声的优势，具有生物相容性的超小型Cu 2–X硒纳米粒子保持用于诊断脑疾病的治疗性治疗的巨大潜力。
更新日期：2018-07-11
中文翻译：
通过可生物降解的超小Cu 2– x Se纳米粒子的无创分子成像监测血脑屏障的开放和恢复
血脑屏障（BBB）的可逆和可控制的开放和恢复对于脑疾病的治疗至关重要，并且以无创方式监测这些过程也是一个巨大的挑战。在本文中，基于超小Cu 2– x Se纳米粒子（3.0 nm）的双模态光声成像和单光子发射计算机断层摄影成像被用于无创地监测活体小鼠聚焦超声诱导的血脑屏障的开放和恢复。 。超小型Cu 2 – x硒纳米颗粒用聚乙二醇改性，表现出较长的血液循环时间。体积小和血液循环时间长，使它们能够在超声的帮助下有效地渗透到大脑中，从而在声处理的部位产生强信号，并允许进行光声和单光子发射计算机断层摄影成像，以监测打开后的恢复情况BBB。生物分布，血液常规检查和组织学染色的结果表明，累积的Cu 2– x Se纳米粒子可以在15天后从大脑和其他主要器官排出，而不会引起副作用。结合无创分子成像和聚焦超声的优势，具有生物相容性的超小型Cu 2–X硒纳米粒子保持用于诊断脑疾病的治疗性治疗的巨大潜力。
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