Use of XtalFluor-E as an Alternative to POCl3 in the Vilsmeier–Haack Formylation of C-2-Glycals,The Journal of Organic Chemistry

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Use of XtalFluor-E as an Alternative to POCl3 in the Vilsmeier–Haack Formylation of C-2-Glycals
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-07-10 00:00:00 , DOI: 10.1021/acs.joc.8b01006
Majdouline Roudias ₁ , Frédéric Vallée ₂ , Julien Martel ₂ , Jean-François Paquin ₁

Affiliation

We report the use of XtalFluor-E ([Et₂NSF₂]BF₄) as an alternative to POCl₃ in the Vilsmeier–Haack formylation reaction of C-2-glycals. Employing a XtalFluor-E/DMF combination allowed the desired C-2-formyl glycals to be isolated in 11–90% yield. This method was extended to the synthesis of a C-2-formylated disaccharide glycal.

中文翻译：

X talFluor-E在C -2-甘醇的Vilsmeier-Haack甲酰化反应中作为POCl ₃的替代物

我们报告了在C -2-糖的Vilsmeier-Haack甲酰化反应中使用XtalFluor-E（[Et ₂ NSF ₂ ] BF ₄）作为POCl ₃的替代物。使用XtalFluor-E / DMF组合可以以11–90％的产率分离出所需的C -2-甲酰基乙二醇。此方法扩展到一个合成C- 2 -甲酰化二糖烯糖。

更新日期：2018-07-10

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