3-Boryl-2,1-borazaronaphthalene: Umpolung Reagents for Diversifying Naphthalene Isosteres,The Journal of Organic Chemistry

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3-Boryl-2,1-borazaronaphthalene: Umpolung Reagents for Diversifying Naphthalene Isosteres
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-07-10 00:00:00 , DOI: 10.1021/acs.joc.8b01197
Jordan S. Compton ₁ , Borna Saeednia ₁ , Christopher B. Kelly ₁ , Gary A. Molander ₁

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A Pd-catalyzed Miyaura borylation of 3-bromo-2,1-borazaronaphthalenes is reported. This method allows the formation of umpolung reagents for subsequent Pd-mediated cross-coupling. Coupling of this nucleophilic partner with a variety of commercially available aryl- and heteroaryl halides allows facile and rapid diversification of these cores.

中文翻译：

3-Boryl-2,1-borazaronaphthaleneene：用于多样化萘等位异构体的Umpolung试剂

据报道，Pd催化了3-溴-2,1-硼硼烷萘的Miyaura硼酸酯化反应。该方法允许形成用于后续的Pd介导的交叉偶联的化学试剂。将该亲核伴侣与各种可商购的芳基卤和杂芳基卤化物偶联，可以使这些核容易而迅速地多样化。

更新日期：2018-07-10

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