Brain endogenous cannabinoid (eCB) signaling seems to harmonize appropriate behavioral responses, which are essential for the organism's long-term viability and homeostasis. Dysregulation of eCB signaling contributes to negative emotional states and increased stress responses. An understanding of the underlying neural cell populations and neural circuit regulation will enable the development of therapeutic strategies to mitigate behavioral maladaptation and provide insight into the influence of eCB on the neural circuits involved in anxiety and depression. This review focuses on recent evidence that has added a new layer of complexity to the idea of targeting the eCB system for therapeutic benefits in neuropsychiatric disease and on the future research direction of neural circuit modulation.

中文翻译：

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在焦虑和抑郁的调节中整合内源性大麻素信号。

脑内源性大麻素 (eCB) 信号似乎可以协调适当的行为反应，这对于生物体的长期生存能力和体内平衡至关重要。eCB 信号的失调会导致消极情绪状态和压力反应增加。了解潜在的神经细胞群和神经回路调节将有助于制定治疗策略，以减轻行为适应不良，并深入了解 eCB 对涉及焦虑和抑郁的神经回路的影响。这篇综述重点关注最近的证据，这些证据为针对 eCB 系统在神经精神疾病中的治疗益处的想法增加了一层新的复杂性，以及神经回路调制的未来研究方向。