Binge eating disorder (BED) is characterized by periods of excessive food intake combined with subjective feelings of loss of control. We examined whether sucrose bingeing itself leads to uncontrolled or compulsive responding and whether this effect is magnified following a period of abstinence. We then assessed dopamine (DA) modulation of inhibitory synaptic transmission in the oval bed nucleus of the stria terminalis (ovBNST) as a neural correlate of compulsive responding and whether this behavioral effect could be disrupted by DA blockade in the ovBNST. Over 28 days, male Long-Evans rats (n = 8-16 per group) had access to 10% sucrose and food (12 or 24 h), 0.1% saccharin and food (12 h), or food alone (12 h). Compulsive responding was assessed following 1 or 28 days of sucrose abstinence using a conditioned suppression paradigm. Only rats given 12 h access to sucrose developed binge-like intake, manifested as copious intake within the first hour; compulsive responding was significantly elevated in this group following 28 days of abstinence. In parallel, the effect of DA on ovBNST inhibitory transmission switched from a reduction to a potentiation; the effect, although observable after 1 day, was more pronounced and sustained following 28 days of abstinence. Intra-ovBNST infusions of a DA D1 receptor antagonist (0.8 µg/µl SCH-23390) reversed the blockade of conditioned suppression, thereby confirming the causal relationship between ovBNST DA modulation of γ-aminobutyric acid transmission and alterations in conditioned suppression following binge-like intake of sucrose.

中文翻译：

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终纹卵圆床核中的多巴胺有助于大鼠对蔗糖的强迫反应。


暴食症（BED）的特点是一段时期食物摄入过多，并伴有主观失控感。我们研究了蔗糖暴食本身是否会导致不受控制或强迫性反应，以及这种影响是否会在禁欲一段时间后放大。然后，我们评估了多巴胺 (DA) 对终纹卵圆床核 (ovBNST) 中抑制性突触传递的调节作为强迫反应的神经相关性，以及这种行为效应是否会被 ovBNST 中的 DA 阻断所破坏。在 28 天的时间里，雄性 Long-Evans 大鼠（每组 n = 8-16 只）可以摄入 10% 蔗糖和食物（12 或 24 小时）、0.1% 糖精和食物（12 小时）或单独食物（12 小时） 。在禁食 1 或 28 天蔗糖后，使用条件抑制范例评估强迫反应。只有给予蔗糖 12 小时的老鼠才会出现暴饮暴食的情况，表现为在第一个小时内大量摄入；禁欲 28 天后，该组的强迫反应显着升高。与此同时，DA 对 ovBNST 抑制传递的作用从减弱转变为增强；尽管 1 天后即可观察到效果，但在禁欲 28 天后效果更加明显和持续。 ovBNST 内输注 DA D1 受体拮抗剂 (0.8 µg/µl SCH-23390) 可逆转条件抑制的阻断，从而证实 ovBNST DA 对 γ-氨基丁酸传输的调节与暴饮暴食后条件抑制的改变之间的因果关系蔗糖的摄入量。