Systematic Evaluation of Sulfoxides as Catalysts in Nucleophilic Substitutions of Alcohols,European Journal of Organic Chemistry

当前位置： X-MOL 学术 › Eur. J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Systematic Evaluation of Sulfoxides as Catalysts in Nucleophilic Substitutions of Alcohols
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-17 , DOI: 10.1002/ejoc.201800907
Sebastian Motsch ₁ , Christian Schütz ₁ , Peter H. Huy ₁

Affiliation

Out of an in‐depth study of a range of sulfinyl compounds in the transformation of alcohols into chloro alkanes emerged (2‐methoxyphenyl)methyl sulfoxide as optimal Lewis base catalyst. While this catalyst allowed the synthesis of benzylic chlorides in turn‐over numbers up to 50, aliphatic alcohols are non‐suitable substrates due to competing Pummerer rearrangement.