Tailor‐Made Functional Peptide Self‐Assembling Nanostructures,Advanced Materials

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Tailor‐Made Functional Peptide Self‐Assembling Nanostructures
Advanced Materials ( IF 27.4 ) Pub Date : 2018-07-10 , DOI: 10.1002/adma.201707083
Moran Amit _{1,

2} , Sivan Yuran ₃ , Ehud Gazit ₄ , Meital Reches ₃ , Nurit Ashkenasy ₁

Affiliation

Noncovalent interactions are the main driving force in the folding of proteins into a 3D functional structure. Motivated by the wish to reveal the mechanisms of the associated self‐assembly processes, scientists are focusing on studying self‐assembly processes of short protein segments (peptides). While this research has led to major advances in the understanding of biological and pathological process, only in recent years has the applicative potential of the resulting self‐assembled peptide assemblies started to be explored. Here, major advances in the development of biomimetic supramolecular peptide assemblies as coatings, gels, and as electroactive materials, are highlighted. The guiding lines for the design of helical peptides, β strand peptides, as well as surface binding monolayer‐forming peptides that can be utilized for a specific function are highlighted. Examples of their applications in diverse immerging applications in, e.g., ecology, biomedicine, and electronics, are described. Taking into account that, in addition to extraordinary design flexibility, these materials are naturally biocompatible and ecologically friendly, and their production is cost effective, the emergence of devices incorporating these biomimetic materials in the market is envisioned in the near future.

中文翻译：

量身定制的功能肽自组装纳米结构。

非共价相互作用是蛋白质折叠成3D功能结构的主要驱动力。由于希望揭示相关的自组装过程的机制，科学家正致力于研究短蛋白片段（肽）的自组装过程。尽管这项研究在生物学和病理学过程的理解上取得了重大进展，但直到最近几年才开始探索由此产生的自组装肽组装体的应用潜力。在此，突出了仿生超分子肽组装体作为涂层，凝胶和电活性材料的开发方面的重大进展。设计螺旋肽，β链肽，突出显示了可用于特定功能的表面结合单层形成肽。描述了它们在例如生态学，生物医学和电子学中的各种浸没应用中的应用实例。考虑到除了出色的设计灵活性外，这些材料还具有自然生物相容性和生态友好性，并且其生产具有成本效益，因此，在不久的将来，市场上将会出现结合这些仿生材料的设备的出现。

更新日期：2018-07-10

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