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Through Scalp and Skull NIR‐II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance
Advanced Materials ( IF 27.4 ) Pub Date : 2018-07-10 , DOI: 10.1002/adma.201802591 Bing Guo 1 , Zonghai Sheng 2 , Dehong Hu 2 , Chengbo Liu 3 , Hairong Zheng 2 , Bin Liu 1
Advanced Materials ( IF 27.4 ) Pub Date : 2018-07-10 , DOI: 10.1002/adma.201802591 Bing Guo 1 , Zonghai Sheng 2 , Dehong Hu 2 , Chengbo Liu 3 , Hairong Zheng 2 , Bin Liu 1
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Brain tumor is one of the most lethal cancers owing to the existence of blood–brain barrier and blood–brain tumor barrier as well as the lack of highly effective brain tumor treatment paradigms. Herein, cyclo(Arg‐Gly‐Asp‐D‐Phe‐Lys(mpa)) decorated biocompatible and photostable conjugated polymer nanoparticles with strong absorption in the second near‐infrared (NIR‐II) window are developed for precise photoacoustic imaging and spatiotemporal photothermal therapy of brain tumor through scalp and skull. Evidenced by the higher efficiency to penetrate scalp and skull for 1064 nm laser as compared to common 808 nm laser, NIR‐II brain‐tumor photothermal therapy is highly effective. In addition, via a real‐time photoacoustic imaging system, the nanoparticles assist clear pinpointing of glioma at a depth of almost 3 mm through scalp and skull with an ultrahigh signal‐to‐background ratio of 90. After spatiotemporal photothermal treatment, the tumor progression is effectively inhibited and the survival spans of mice are significantly extended. This study demonstrates that NIR‐II conjugated polymer nanoparticles are promising for precise imaging and treatment of brain tumors.
中文翻译：
通过头皮和颅骨NIR-II光热疗法对原位深部脑肿瘤进行精确的光声成像指导
由于存在血脑屏障和血脑肿瘤屏障以及缺乏高效的脑肿瘤治疗范例，脑肿瘤是最致命的癌症之一。在此，开发了在第二个近红外（NIR-II）窗口中具有强吸收性的，具有环（Arg-Gly-Asp-D-Phe-Lys（mpa））装饰的生物相容性和光稳定的共轭聚合物纳米颗粒，用于精确的光声成像和时空光热通过头皮和颅骨治疗脑肿瘤。与普通的808 nm激光相比，1064 nm激光具有更高的穿透头皮和颅骨的效率，证明了NIR-II脑肿瘤光热疗法非常有效。此外，通过实时光声成像系统，纳米颗粒可通过头皮和颅骨在近3 mm的深度处清晰地定位神经胶质瘤，信噪比超高至90。在进行时空光热处理后，可有效抑制肿瘤的进展，并显着延长小鼠的生存期。这项研究表明，NIR-II共轭聚合物纳米颗粒有望用于脑肿瘤的精确成像和治疗。
更新日期：2018-07-10
中文翻译：
通过头皮和颅骨NIR-II光热疗法对原位深部脑肿瘤进行精确的光声成像指导
由于存在血脑屏障和血脑肿瘤屏障以及缺乏高效的脑肿瘤治疗范例，脑肿瘤是最致命的癌症之一。在此，开发了在第二个近红外（NIR-II）窗口中具有强吸收性的，具有环（Arg-Gly-Asp-D-Phe-Lys（mpa））装饰的生物相容性和光稳定的共轭聚合物纳米颗粒，用于精确的光声成像和时空光热通过头皮和颅骨治疗脑肿瘤。与普通的808 nm激光相比，1064 nm激光具有更高的穿透头皮和颅骨的效率，证明了NIR-II脑肿瘤光热疗法非常有效。此外，通过实时光声成像系统，纳米颗粒可通过头皮和颅骨在近3 mm的深度处清晰地定位神经胶质瘤，信噪比超高至90。在进行时空光热处理后，可有效抑制肿瘤的进展，并显着延长小鼠的生存期。这项研究表明，NIR-II共轭聚合物纳米颗粒有望用于脑肿瘤的精确成像和治疗。
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