Silyl enol etherification by a Tf2NH/amine co-catalytic system for minimizing hazardous waste generation†,Reaction Chemistry & Engineering

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Silyl enol etherification by a Tf2NH/amine co-catalytic system for minimizing hazardous waste generation†
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2018-07-11 00:00:00 , DOI: 10.1039/c8re00039e
Kei Kurahashi _{1,

2,

3,

4} , Yousuke Yamaoka _{1,

2,

3,

4} , Yoshiji Takemoto _{1,

2,

3,

4} , Kiyosei Takasu _{1,

2,

3,

4}

Affiliation

A practical silyl enol etherification of ketones with allylsilanes catalyzed by a Tf₂NH–amine co-catalyst under mild conditions has been developed. The reaction generated only volatile isobutene gas as waste. Moreover, a multi-gram synthesis using a microfluidic system and a domino silyl enol etherification–(2 + 2) cycloaddition reaction were demonstrated.

中文翻译：

通过Tf ₂ NH /胺共催化系统进行甲硅烷基烯醇醚化，可最大程度减少有害废物的产生†

已经开发了一种在温和条件下由Tf ₂ NH-胺助催化剂催化的用烯丙基硅烷将酮进行甲硅烷基烯醇醚化的实用方法。该反应仅产生挥发性的异丁烯气体作为废物。此外，还证明了使用微流体系统和多米诺硅烷基烯醇醚化-（2 + 2）环加成反应的多克合成反应。

更新日期：2018-07-11

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