Integrated plug flow synthesis and crystallisation of pyrazinamide†,Reaction Chemistry & Engineering

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Integrated plug flow synthesis and crystallisation of pyrazinamide†
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2018-07-10 00:00:00 , DOI: 10.1039/c8re00087e
C. Daniel Scott _{1,

2,

3,

4} , Ricardo Labes _{2,

4,

5} , Martin Depardieu _{2,

3,

4} , Claudio Battilocchio _{2,

4,

5} , Matthew G. Davidson _{1,

2,

3,

4} , Steven V. Ley _{2,

4,

5} , Chick C. Wilson _{1,

2,

3,

4,

6} , Karen Robertson _{2,

3,

4}

Affiliation

We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO₂. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.

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