Lactobacillus plantarum ZDY04 exhibits a strain-specific property of lowering TMAO via the modulation of gut microbiota in mice,Food & Function

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Lactobacillus plantarum ZDY04 exhibits a strain-specific property of lowering TMAO via the modulation of gut microbiota in mice
Food & Function ( IF 5.1 ) Pub Date : 2018-07-10 , DOI: 10.1039/c8fo00349a
Liang Qiu _{1,

2,

3,

4,

5} , Xueying Tao _{1,

2,

3,

4} , Hua Xiong _{1,

2,

3,

4} , Jun Yu _{3,

4,

5} , Hua Wei _{1,

2,

3,

4}

Affiliation

Trimethylamine N-oxide (TMAO), which is oxidized from trimethylamine (TMA) by hepatic flavin-containing monooxygenases (FMOs), promotes the development of atherosclerosis and is a new target for the prevention and treatment of cardiovascular disease from the perspective of intestinal flora. TMA is transformed by intestinal flora from TMA-containing nutrients, such as choline. Some small molecular agents lower serum TMAO and/or cecal TMA levels. However, probiotics that can effectively reduce serum TMAO levels are currently lacking. In this work, five potentially probiotic strains were administered to mice supplemented with 1.3% choline. Only Lactobacillus plantarum ZDY04 significantly reduced serum TMAO and cecal TMA levels by modulating the relative abundance of the families Lachnospiraceae, Erysipelotrichaceae and Bacteroidaceae and the genus Mucispirillum in mice and not by influencing the expression levels of hepatic FMO3 and metabolizing choline, TMA, and TMAO. In addition, L. plantarum ZDY04 can significantly inhibit the development of TMAO-induced atherosclerosis in ApoE^−/− 1.3% choline-fed mice as compared with the untreated PBS group. In conclusion, the use of L. plantarum ZDY04 may be an alternative approach to reduce serum TMAO levels and TMAO-induced atherosclerosis in mice.

中文翻译：

植物乳杆菌ZDY04表现出通过调节小鼠肠道菌群来降低TMAO的菌株特异性特性

从含有甲黄素的单加氧酶（FMOs）的三甲胺（TMA）氧化而得的三甲胺N-氧化物（TMAO）促进动脉粥样硬化的发展，从肠道菌群的角度来看，它是预防和治疗心血管疾病的新目标。TMA由含有TMA的营养物质（例如胆碱）转化成肠道菌群。一些小分子药物可降低血清TMAO和/或盲肠TMA水平。但是，目前缺乏能够有效降低血清TMAO水平的益生菌。在这项工作中，向添加了1.3％胆碱的小鼠施用了五种潜在的益生菌菌株。仅植物乳杆菌ZDY04可以通过调节小鼠鼠鼻螺旋藻科，丹参和拟杆菌科以及粘螺旋藻属的相对丰度来显着降低血清TMAO和盲肠TMA水平，而不会影响肝脏FMO3的表达水平以及代谢胆碱，TMA和TMAO。此外，与未经处理的PBS组相比，植物乳杆菌ZDY04可以显着抑制ApoE ^-/- 1.3％胆碱喂养的小鼠中TMAO诱导的动脉粥样硬化的发展。总之，使用植物乳杆菌ZDY04可能是降低小鼠血清TMAO水平和TMAO诱导的动脉粥样硬化的另一种方法。

更新日期：2018-08-15

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