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A spent hen muscle protein hydrolysate: a potential IL-10 stimulator in a murine model
Food & Function ( IF 5.1 ) Pub Date : 2018-07-10 00:00:00 , DOI: 10.1039/c8fo00589c Wenlin Yu 1, 2, 3, 4, 5 , Catherine J. Field 1, 2, 3, 4, 5 , Jianping Wu 1, 2, 3, 4, 5
Food & Function ( IF 5.1 ) Pub Date : 2018-07-10 00:00:00 , DOI: 10.1039/c8fo00589c Wenlin Yu 1, 2, 3, 4, 5 , Catherine J. Field 1, 2, 3, 4, 5 , Jianping Wu 1, 2, 3, 4, 5
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Dietary proteins harbour bioactive peptides that exert various physiological activities. Chicken meat prepared from spent layers from the egg industry is an inexpensive source of protein for the production of bioactive peptides. This study explored the effect of hen muscle-derived peptides prepared by enzymatic hydrolysis on immune functions. The hydrolysate was incorporated into the diet of weanling Sprague-Dawley rats (n = 8 per diet) for 3 weeks at 2% or 5% addition (w/w diet). At a dose of 5% (w/w) the hydrolysate exhibited immunomodulatory effects on splenocytes, including a lower proportion of OX6+ (professional antigen presenting cells) and a higher proportion of CD11b/c+ cells (macrophages/monocytes) (p < 0.05) compared to the isonitrogenous control diet. Meanwhile, the production of anti-inflammatory cytokine interleukin (IL)-10 by splenocytes stimulated ex vivo with mitogens was significantly higher from hydrolysate treatment; there was no significant difference in the other cytokines (IL-1β, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-6 and IL-2) investigated. Supplementing with the hydrolysate did not alter the growth, food intake and organ weights in young rodents. These results indicated that the spent hen muscle protein hydrolysate has the potential to be developed for value-added products with anti-inflammatory properties.
中文翻译：
用过的鸡肌肉蛋白水解物：鼠模型中潜在的IL-10刺激物
饮食蛋白含有发挥各种生理活性的生物活性肽。由鸡蛋工业的废料层制备的鸡肉是用于生产生物活性肽的廉价蛋白质来源。这项研究探讨了酶水解制备的母鸡肌肉衍生肽对免疫功能的影响。在添加2％或5％（w / w饮食）的情况下，将水解产物掺入断奶的Sprague-Dawley大鼠的饮食中（每饮食n = 8），持续3周。在5％（w / w）的剂量下，水解产物对脾细胞表现出免疫调节作用，包括较低比例的OX6 +（专业抗原呈递细胞）和较高比例的CD11b / c +细胞（巨噬细胞/单核细胞）（p<0.05）与同氮对照饮食相比。同时，水解产物处理后，有丝分裂原体外刺激的脾细胞产生的抗炎细胞因子白介素（IL）-10的产生显着增加。研究的其他细胞因子（IL-1β，肿瘤坏死因子（TNF）-α，干扰素（IFN）-γ，IL-6和IL-2）没有显着差异。补充水解产物不会改变幼小啮齿动物的生长，食物摄入和器官重量。这些结果表明，废鸡肌肉蛋白水解物具有开发具有抗炎特性的增值产品的潜力。
更新日期：2018-07-10
中文翻译：
用过的鸡肌肉蛋白水解物：鼠模型中潜在的IL-10刺激物
饮食蛋白含有发挥各种生理活性的生物活性肽。由鸡蛋工业的废料层制备的鸡肉是用于生产生物活性肽的廉价蛋白质来源。这项研究探讨了酶水解制备的母鸡肌肉衍生肽对免疫功能的影响。在添加2％或5％（w / w饮食）的情况下，将水解产物掺入断奶的Sprague-Dawley大鼠的饮食中（每饮食n = 8），持续3周。在5％（w / w）的剂量下，水解产物对脾细胞表现出免疫调节作用，包括较低比例的OX6 +（专业抗原呈递细胞）和较高比例的CD11b / c +细胞（巨噬细胞/单核细胞）（p<0.05）与同氮对照饮食相比。同时，水解产物处理后，有丝分裂原体外刺激的脾细胞产生的抗炎细胞因子白介素（IL）-10的产生显着增加。研究的其他细胞因子（IL-1β，肿瘤坏死因子（TNF）-α，干扰素（IFN）-γ，IL-6和IL-2）没有显着差异。补充水解产物不会改变幼小啮齿动物的生长，食物摄入和器官重量。这些结果表明，废鸡肌肉蛋白水解物具有开发具有抗炎特性的增值产品的潜力。
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