IR820 covalently linked with self-assembled polypeptide for photothermal therapy applications in cancer†,Biomaterials Science

当前位置： X-MOL 学术 › Biomater. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

IR820 covalently linked with self-assembled polypeptide for photothermal therapy applications in cancer†
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-07-10 00:00:00 , DOI: 10.1039/c8bm00399h
Kaizong Huang _{1,

2,

3,

4,

5} , Mengyue Gao _{5,

6,

7,

8,

9} , Lin Fan _{5,

10,

11,

12} , Yueyang Lai _{5,

6,

7,

8,

9} , Hongwei Fan _{1,

2,

3,

4,

5} , Zichun Hua _{5,

6,

7,

8,

9}

Affiliation

Owing to the unique advantages of high specificity and minimal invasiveness, photothermal therapy (PTT) has been evidenced with great potential in cancer treatment. However, most photothermal agents present a shortage of photobleaching and nonspecific biodistribution in clinical application. In this study, we conjugated a new Indocyanine Green Dye (IR820) with self-assembled polypeptide (ELP) via chemical bonding in an aqueous environment. This preparation method could effectively avoid damaging the polypeptide. ELP-IR820 was fabricated as nanoconjugates with diameters of approximately 50 nm. The use of ELP-IR820 notably enhanced photothermal-mediated cytotoxicity on CT-26 cancer cells. We demonstrate that the ELP-IR820 nanoparticles significantly improved drug accumulation in the tumor and photothermal effect in vivo compared to the free dye and monomer ELP-IR820. ELP-IR820 nanoparticle also exhibited outstanding ability to cause prominent tumor tissue growth inhibition via the photothermal effect. No noticeable toxicity was detected for all treatment groups. These investigations broaden the application of NIR dyes as a multimodal photothermal therapy platform.

中文翻译：

IR820与自组装多肽共价连接，可用于癌症的光热疗法†

由于高特异性和微创性的独特优势，已证明光热疗法（PTT）在癌症治疗中具有巨大潜力。然而，大多数光热剂在临床应用中存在光漂白和非特异性生物分布的短缺。在这项研究中，我们结合了新的吲哚菁绿染料（IR820）具有自装配的多肽（ELP）经由在水性环境中的化学键合。该制备方法可有效避免多肽的破坏。ELP-IR820被制成直径约为50 nm的纳米共轭物。ELP-IR820的使用显着增强了对CT-26癌细胞的光热介导的细胞毒性。我们证明，与游离染料和单体ELP-IR820相比，ELP-IR820纳米粒子显着改善了肿瘤在体内的药物蓄积和体内的光热效应。ELP-IR820纳米颗粒还表现出杰出的通过光热效应引起明显的肿瘤组织生长抑制的能力。在所有治疗组中均未检测到明显的毒性。这些研究拓宽了近红外染料作为多模式光热疗法平台的应用。

更新日期：2018-07-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11