Salvia miltiorrhiza (Danshen in Chinese), is a well-known traditional Chinese medicinal plant, which is used as not only human medicine but also health-promotion food. Danshen has been extensively used for the treatment of various cardiovascular and cerebrovascular diseases. As a major group of bioactive constituents from S. miltiorrhiza, water-soluble phenolic acids such as salvianolic acid B possessed good bioactivities including antioxidant, anti-inflammatory, anti-cancer and other health-promoting activities. It is of significance to improve the production of phenolic acids by modern biotechnology approaches to meet the increasing market demand. Significant progresses have been made in understanding the biosynthetic pathway and regulation mechanism of phenolic acids in S.miltiorrhiza, which will facilitate the process of targeted metabolic engineering or synthetic biology. Furthermore, multiple biotechnology methods such as in vitro culture, elicitation, hairy roots, endophytic fungi and bioreactors have been also used to obtain pharmaceutically active phenolic acids from S. miltiorrhiza. In this review, recent advances in bioactivities, biosynthetic pathway and biotechnological production of phenolic acid ingredients were summarized and future prospective was also discussed.

中文翻译：

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丹参中酚酸的生物活性，生物合成和生物技术生产

丹参（Salvia miltiorrhiza）（丹参）是一种著名的传统中草药植物，不仅用作人体药物，而且还用作促进健康的食品。丹参已被广泛用于治疗各种心脑血管疾病。如从生物活性成分的主要组丹参，水溶性酚醛酸如酚酸B具有良好的生物活性，包括抗氧化剂，抗发炎，抗癌症和其它促进健康的活动。通过现代生物技术方法提高酚酸的生产以满足日益增长的市场需求具有重要意义。酚酸的生物合成途径及其调控机理的研究取得了重要进展。S.miltiorrhiza，这将有助于目标代谢工程或合成生物学的过程。此外，还已经使用多种生物技术方法，例如体外培养，诱导，毛状根，内生真菌和生物反应器，来从乳链球菌中获得药学活性的酚酸。在这篇综述中，总结了酚酸成分的生物活性，生物合成途径和生物技术生产方面的最新进展，并对未来的前景进行了讨论。