A Substitution‐Dependent Light‐Up Fluorescence Probe for Selectively Detecting Fe3+ Ions and Its Cell Imaging Application,Advanced Functional Materials

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A Substitution‐Dependent Light‐Up Fluorescence Probe for Selectively Detecting Fe3+ Ions and Its Cell Imaging Application
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-07-08 , DOI: 10.1002/adfm.201802833
Xing Feng _{1,

2} , Ying Li ₁ , Xuewen He ₁ , Haixiang Liu ₁ , Zheng Zhao ₁ , Ryan T. K. Kwok ₁ , Mark R. J. Elsegood ₃ , Jacky W. Y. Lam ₁ , Ben Zhong Tang _{1,

4,

5}

Affiliation

Deliberate design of specific and sensitive molecular probes with distinctive physical/chemical properties for analyte sensing is of great significance. Herein, by taking advantage of the position‐dependent substituent effects, an aggregation‐induced emission featured iron (III) probe from ortho‐substituted pyridinyl‐functionalized tetraphenylethylene (TPE‐o‐Py) is synthesized. It displays high sensitivity and selectivity toward iron (III) detection. The recognition arises from the position isomer of ortho‐substitution, and the fact that TPE‐o‐Py has a low acid dissociation constant (pK _a) that is close to that of hydrolyzed Fe³⁺. Importantly, TPE‐o‐Py as a light‐up fluorescence probe could be employed for Fe³⁺ sensing in living cells with a pronounced red‐shift in fluorescence emission.

中文翻译：

选择性检测Fe3 +离子的取代依赖性发光荧光探针及其细胞成像应用

精心设计具有独特物理/化学性质的特异性和灵敏分子探针，以进行分析物检测具有重要意义。在此，通过利用位置依赖的取代基效应，从邻位取代的吡啶基官能化的四苯基乙烯（TPE- o- Py）合成了聚集诱导的发射特征铁（III）探针。它对铁（III）检测显示出高灵敏度和选择性。这种认识源于邻位取代的位置异构体，以及TPE- o- Py具有接近于水解Fe ³⁺的低酸解离常数（p K _a）的事实。重要的是，TPE- o‐Py作为发光的荧光探针可用于活细胞中Fe ^3+的传感，且荧光发射具有明显的红移。

更新日期：2018-07-08

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