Cancer Therapy: Integrated Combination Treatment Using a “Smart” Chemotherapy and MicroRNA Delivery System Improves Outcomes in an Orthotopic Colorectal Cancer Model (Adv. Funct. Mater. 28/2018),Advanced Functional Materials

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Cancer Therapy: Integrated Combination Treatment Using a “Smart” Chemotherapy and MicroRNA Delivery System Improves Outcomes in an Orthotopic Colorectal Cancer Model (Adv. Funct. Mater. 28/2018)
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-07-09 , DOI: 10.1002/adfm.201870196
Hai-Jun Liu ₁ , Xin Luan ₁ , Hai-Yi Feng ₁ , Xiao Dong ₁ , Si-Cong Yang ₁ , Zhong-Jian Chen ₁ , Qin-Yi Cai ₁ , Qin Lu ₁ , Yunpeng Zhang ₂ , Peng Sun ₂ , Mei Zhao ₃ , Hong-Zhuan Chen ₁ , Jonathan F. Lovell ₄ , Chao Fang ₁

Affiliation

In article number 1801118 Mei Zhao, Chao Fang, and co‐workers develop a smart mesoporous silica nanoparticles (MSN) based nanosystem for doxorubicin and microRNA‐145 co‐delivery (Dm@TMSN). By “weaving” polyethylenimine on the MSN surface through disulfide bonds the counter‐productive dilemma generated from intracellular compartment‐dependent delivery and release of both cargos is overcome. By integrating a peptide‐mediated active targeting strategy, Dm@TMSN exhibits an excellent antitumor effect in an orthotopic colorectal cancer model.

中文翻译：

癌症治疗：使用“智能”化学疗法和MicroRNA递送系统的综合联合治疗可改善原位结直肠癌模型的结果（Adv。Funct。Mater。28/2018）

在文章1801118中，赵玫，赵超和同事开发了一种基于智能中孔二氧化硅纳米粒子（MSN）的纳米系统，用于阿霉素和microRNA-145共递送（Dm @ TMSN）。通过通过二硫键在MSN表面“编织”聚乙烯亚胺，可以克服两种货物在细胞内区室依赖性递送和释放中产生的适得其反的困境。通过整合肽介导的主动靶向策略，Dm @ TMSN在原位结直肠癌模型中表现出出色的抗肿瘤作用。

更新日期：2018-07-09

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