The cover feature picture shows direct DNA recognition of a peptide nucleic acid (PNA) conjugate–Ru complex (Ru‐PNA) by double duplex invasion. As Ru‐PNA is anchored to DNA by the additional interaction of the Ru complex with DNA, Ru‐PNA forms a more stable duplex with DNA. This higher DNA binding affinity enhances the invasion efficiency even at physiological salt concentrations. More information can be found in the communication by Y. Aiba, O. Shoji, et al. on page 1601 in Issue 15, 2018 (DOI: 10.1002/cbic.201800256).

中文翻译：

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封面功能：即使在生理条件下，肽核酸也能与钌配合物稳定的双链体侵入复合物结合（ChemBioChem 15/2018）

封面特征图片显示了通过双双工入侵直接识别肽核酸（PNA）共轭-Ru复合物（Ru-PNA）的DNA。由于Ru-PNA通过Ru复合物与DNA的额外相互作用而锚定在DNA上，因此Ru-PNA与DNA形成了更稳定的双链体。这种更高的DNA结合亲和力即使在生理盐浓度下也能提高入侵效率。可以在Y. Aiba，O。Shoji等人的来文中找到更多信息。就在第15期，2018页1601（：10.1002 / cbic.201800256 DOI）。