AbstractTwo-dimensional tellurium nanosheets were prepared by a hydrothermal method and characterized by scanning electron microscopy, powder X-ray diffractometry, and UV-vis spectroscopy. The nanosheets were explored as a novel matrix for desorption/ionization of small molecules including nucleobases, fatty acids and amino acids by matrix assisted laser desorption/ionization time-of-flight mass spectrometry. The results show that the tellurium nanosheets have good UV light absorption, cause low matrix ion interference in the low-molecule-mass region, and have high desorption/ionization efficiency in the negative ion mode. Hence, they are a viable matrix for negative ion desorption/ionization in MALDI-TOF MS of small molecules. In order to investigate the desorption/ionization mechanisms, benzylpyridinium salt and bisphenol A were adopted as probes. The results show that both of the electronic transitions mechanism and laser-induced thermal mechanism play important roles in desorption/ionization process. Graphical abstractTwo-dimensional tellurium (Te) nanosheet was synthesized by a hydrothermal method and explored as a novel matrix for desorption/ionization of small molecules by matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).

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用于小分子基质辅助激光解吸/电离飞行时间质谱的碲纳米片的合成

摘要 采用水热法制备二维碲纳米片，并通过扫描电子显微镜、粉末X射线衍射和紫外-可见光谱对其进行表征。通过基质辅助激光解吸/电离飞行时间质谱法，将纳米片作为一种新的基质，用于解吸/电离包括核碱基、脂肪酸和氨基酸在内的小分子。结果表明，碲纳米片具有良好的紫外光吸收性，在低分子质量区引起的基体离子干扰小，在负离子模式下具有较高的解吸/电离效率。因此，它们是小分子 MALDI-TOF MS 中负离子解吸/电离的可行基质。为了研究解吸/电离机制，采用苄基吡啶鎓盐和双酚A作为探针。结果表明，电子跃迁机制和激光诱导热机制在解吸/电离过程中都起着重要作用。图形摘要通过水热法合成二维碲 (Te) 纳米片，并通过基质辅助激光解吸/电离飞行时间质谱 (MALDI-TOF MS) 探索作为小分子解吸/电离的新型基质。