AbstractPoly(2-naphthyl acrylate) was first grafted onto silica-coated magnetic nanoparticles by surface-initiated atom transfer radical polymerization to prepare a reversed-phase magnetic adsorbent. The resulting polymer brush displays enhanced extraction efficiency by offering active sites on the surfaces of adsorbent. It was applied to the preconcentration of the non-steroidal antiinflammatory drugs (NSAIDs) indomethacin (InDo) and diclofenac (DIC). These drugs interact with the sorbent through hydrophobic and π-interactions, and via electrostatic attraction. By coupling the magnetic solid-phase extraction with HPLC, a method for analysis of InDo and DIC in the environmental water samples was established. The limits of detection range from 0.62 to 0.64 ng·mL−1, and the relative standard deviations for intra-and inter-day analyses of spiked water samples are <11.9%, and relative recoveries are between 62.1 and 96.7%. Graphical abstractA reversed-phase magnetic adsorbent was prepared by grafting poly(2-naphthyl acrylate) brush on the surface of silica coated magnetic nanoparticles. Due to the two conjugated aromatic rings of the monomer, the polymer brush can effectively extract non-steroidal anti-inflammatory drugs through strong π- and hydrophobic interactions.

中文翻译：

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用于富集非甾体抗炎药吲哚美辛和双氯芬酸的萘基聚合物悬垂接枝磁性吸附剂

摘要 首先通过表面引发的原子转移自由基聚合将聚（2-萘基丙烯酸酯）接枝到二氧化硅包覆的磁性纳米粒子上，制备了反相磁性吸附剂。通过在吸附剂表面提供活性位点，由此产生的聚合物刷显示出更高的提取效率。它被应用于非甾体抗炎药 (NSAIDs) 吲哚美辛 (InDo) 和双氯芬酸 (DIC) 的预浓缩。这些药物通过疏水和 π 相互作用以及静电吸引与吸附剂相互作用。通过磁性固相萃取与高效液相色谱联用，建立了环境水样中InDo和DIC的分析方法。检测限范围为 0.62 至 0.64 ng·mL−1，加标水样日内和日间分析的相对标准偏差<11.9%，相对回收率在62.1-96.7%之间。图形摘要通过在二氧化硅包覆的磁性纳米粒子表面接枝聚（2-萘基丙烯酸酯）刷制备反相磁性吸附剂。由于单体的两个共轭芳环，聚合物刷可以通过强π-和疏水相互作用有效提取非甾体抗炎药。