Stimuli-responsive metal–organic supercontainers as synthetic proton receptors†,Dalton Transactions

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Stimuli-responsive metal–organic supercontainers as synthetic proton receptors†
Dalton Transactions ( IF 3.5 ) Pub Date : 2018-07-09 00:00:00 , DOI: 10.1039/c8dt01900b
Cheng-Zhe Sun _{1,

2,

3,

4,

5} , Li-Ji Cheng _{1,

2,

3,

4,

5} , Yupu Qiao _{6,

7,

8,

9} , Li-Yi Zhang _{1,

2,

3,

4,

5} , Zhong-Ning Chen _{1,

2,

3,

4,

5} , Feng-Rong Dai _{1,

2,

3,

4,

5} , Wei Lin _{9,

10,

11,

12} , Zhenqiang Wang _{6,

7,

8,

9}

Affiliation

We demonstrate a proof-of-concept design of a new platform for proton recognition and modulation. The new proton receptors are derived from a unique class of synthetic supercontainers that exhibit exceptional proton binding capacity (over 50 equiv.) and intriguing proton-dependent fluorescent switching behavior. Experimental and computational studies suggest that the proton-responsive event involves a two-step mechanism pertaining to proton binding by both amino and pyrenyl moieties of the supercontainer constructs. The high proton binding capacity of the supercontainers can be further modulated via small-molecule “regulators” that compete for the proton-binding sites, opening exiting new opportunities for proton manipulation in both chemistry and biology.

中文翻译：

刺激反应性金属有机超容器作为合成质子受体†

我们演示了用于质子识别和调制的新平台的概念验证设计。新的质子受体衍生自一类独特的合成超容器，这些超容器具有出色的质子结合能力（超过50当量）和令人着迷的质子依赖性荧光转换行为。实验和计算研究表明，质子响应事件涉及两步机制，该机制涉及超容器构建体的氨基和pyr基部分的质子结合。超级容器的高质子结合能力可以通过竞争质子结合位点的小分子“调节剂”来进一步调节，从而为化学和生物学中的质子操纵开辟了新的机遇。

更新日期：2018-07-09

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