A plausible model correlates prebiotic peptide synthesis with the primordial genetic code†,Chemical Communications

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A plausible model correlates prebiotic peptide synthesis with the primordial genetic code†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-07-07 00:00:00 , DOI: 10.1039/c8cc04767g
Jianxi Ying _{1,

2,

3,

4,

5} , Songsen Fu _{1,

2,

3,

4,

5} , Xin Li _{1,

2,

3,

4,

5} , Liubin Feng _{1,

2,

3,

4,

5} , Pengxiang Xu _{1,

2,

3,

4,

5} , Yan Liu _{1,

2,

3,

4,

5} , Xiang Gao _{4,

5,

6,

7} , Yufen Zhao _{1,

2,

3,

4,

5}

Affiliation

Aminoacyladenylates (5′-aa-AMPs) are key intermediates in peptide synthesis. Here we report analogs of 5′-aa-AMPs, namely nucleotide amidates (aa-N-NMPs), obtained under Hadean conditions. Significantly, dipeptides were detected from the above reactions and their yields varied with different nucleosides through the formation of different aa-N-NMPs. This model provides both prebiotic peptides and the primordial version of the genetic code through reactions that occurred under potentially prebiotic conditions.

中文翻译：

一个可行的模型将益生元肽的合成与原始遗传密码相关联†

氨基酰基腺苷酸（5'-aa-AMPs）是肽合成中的关键中间体。在这里，我们报告在Hadean条件下获得的5'-aa-AMPs的类似物，即核苷酸酰胺化物（aa- N -NMPs）。显着地，从以上反应中检测到二肽，并且其产率通过形成不同的aa- N- NMP而随不同的核苷而变化。该模型通过在潜在的益生元条件下发生的反应提供了益生元肽和遗传密码的原始版本。

更新日期：2018-07-07

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