DNA‐Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole,ChemBioChem

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DNA‐Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole
ChemBioChem ( IF 2.6 ) Pub Date : 2018-08-15 , DOI: 10.1002/cbic.201800273
Beibei Liu ₁ , Luke Pett ₂ , Konstantinos Kiakos ₂ , Pravin C. Patil ₃ , Vijay Satam ₃ , John A. Hartley ₂ , Moses Lee _{1,

3,

4} , W. David Wilson ₁

Affiliation

In a bind: Modification of 2‐(p‐anisyl)‐4‐azabenzimidazole (AzaHx) to (p‐pyridyl)‐4‐azabenzimidazole(Pyr‐AzaHx) does not enable the molecule to recognize GG dinucleotides specifically; instead, 3‐Pyr‐AzaHx improves binding affinity, possibly as a result of protonation of the pyrido nitrogen atom.

中文翻译：

新型荧光AzaHx酰胺的DNA结合特性：甲氧基吡啶基氮杂苯并咪唑吡咯并咪唑/吡咯

绑定中：将2-（对-茴香基）-4-氮杂苯并咪唑（AzaHx）修饰为（p-吡啶基）-4-氮杂苯并咪唑（Pyr-AzaHx）不能使分子特异性识别GG二核苷酸。相反，3-Pyr-AzaHx可以提高结合亲和力，这可能是吡啶氮原子质子化的结果。

更新日期：2018-08-15

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