Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations,European Journal of Organic Chemistry

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Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-20 , DOI: 10.1002/ejoc.201800799
Andrew Gomm ₁ , Stylianos Grigoriou ₁ , Christopher Peel ₁ , James Ryan ₁ , Nafees Mujtaba ₁ , Thomas Clarke ₁ , Evelina Kulcinskaja ₁ , Elaine O'Reilly ₁

Affiliation

The “smart” amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using a commercially available amine transaminase, ATA256. The methodology enables both screening and preparative‐scale biotransformations to be performed with a single enzyme and simplifies the generation of sp3‐rich small‐molecule libraries.

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