A new azaphilone derivative, named peniazaphilin A (1) and one known isocoumarin, (R)-3-methyl-6-hydroxy-8-methoxy-3,4-dihydroisocoumarin (2) were isolated from the fungus Penicillium sp. CPCC 400786. Their structures were elucidated by means of extensive spectroscopic analysis. The absolute configuration of 2 was established by circular dichroism for the first time. Compounds 1 and 2 exhibited weak anti-HIV activities with the IC₅₀ values of 60.4 and 69.3 μM, respectively.

中文翻译：

---

Peniazaphilin A，一种由Penicillium sp。生产的新的azaphilone衍生物。CPCC 400786。

从真菌Penicillium sp。分离出一种新的氮杂苯醌衍生物，命名为peniazaphilin A（1）和一种已知的异香豆素，（R）-3-甲基-6-羟基-8-甲氧基-3,4-二氢异香豆素（2）。CPCC400786。通过广泛的光谱分析阐明了它们的结构。2的绝对构型是首次通过圆二色性建立的。化合物1和2表现出较弱的抗HIV活性，IC ₅₀值分别为60.4和69.3μM。