Photoactive Oligo(p-phenylenevinylene) Functionalized with Phospholipid Units for Control and Visualization of Delivery into Living Cells,ACS Applied Materials & Interfaces

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Photoactive Oligo(p-phenylenevinylene) Functionalized with Phospholipid Units for Control and Visualization of Delivery into Living Cells
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-07-06 00:00:00 , DOI: 10.1021/acsami.8b07847
Yanyan Chen _{1,

2} , Lingyun Zhou _{1,

2} , Jianwu Wang _{1,

2} , Xiaoyan Liu ₃ , Huan Lu ₁ , Libing Liu _{1,

2} , Fengting Lv ₁ , Shu Wang _{1,

2}

Affiliation

To take advantage of the excellent optical properties of conjugated polymers (CPs) or conjugated oligomers (COs) for biological applications, there is still a requirement to find new ways to deliver these conjugated molecular materials into cells in a facile, controllable, and noninvasive manner. Herein, a photoactive oligo(p-phenylenevinylene) (OPV) derivative was covalently attached with phospholipid units (OPV–lipid) to enhance its dispersion in water and facilitate its internalization by cells. OPV–lipid could be delivered into either the cell membrane or cytoplasm controllably through the assistance of liposomes with different formulas. It could also act as a fluorescent probe for cell imaging and visualization of the delivery process. This work shows a good potential for delivering functional conjugated molecular materials into cells in a controllable way.

中文翻译：

用磷脂单元功能化的光活性寡聚（对-苯基亚乙烯基），用于控制和可视化递送到活细胞中

为了在生物应用中利用共轭聚合物（CP）或共轭低聚物（CO）的出色光学性质，仍然需要寻找新的方法，以方便，可控且无创的方式将这些共轭分子材料输送到细胞中。在此，光活性寡聚物（p-苯基亚乙烯基）（OPV）衍生物与磷脂单元（OPV-脂质）共价连接，以增强其在水中的分散性并促进其被细胞内在化。通过不同配方的脂质体，OPV-脂质可以可控地传递到细胞膜或细胞质中。它也可以用作细胞成像和递送过程可视化的荧光探针。这项工作显示出以可控制的方式将功能性共轭分子材料递送到细胞中的良好潜力。

更新日期：2018-07-06

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