当前位置：
X-MOL 学术
›
Phytochemistry
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Aporphine Alkaloids from Illigera aromatica from Guangxi Province, China
Phytochemistry ( IF 3.8 ) Pub Date : 2018-10-01 , DOI: 10.1016/j.phytochem.2018.06.017 Yi-Chao Ge , Hai-Jiang Zhang , Kui-Wu Wang , Xin-Feng Fan
Phytochemistry ( IF 3.8 ) Pub Date : 2018-10-01 , DOI: 10.1016/j.phytochem.2018.06.017 Yi-Chao Ge , Hai-Jiang Zhang , Kui-Wu Wang , Xin-Feng Fan
Three undescribed aporphine alkaloids laurodionine B (1), illigerine A (2), and N-formyl-laurolitsine (3) were isolated from the methanolic extracts of the Chinese medicinal plant, Illigera aromatica, together with three known analogues (4-6). The chemical structures of 1-6 were identified by spectroscopic methods including 1D and 2D NMR (1H, 13C, COSY, HSQC, and HMBC) and high resolution mass spectrometry (HRESIMS). Compounds 1-3 showed moderate inhibitory activities in vitro against two cultured tumor cell lines, Hela and SMMC7721, with IC50 values of 32.42-62.90 μM. Only compound 1 had in vitro cytotoxic activity against Bcap37 cells, with the IC50 value of 90.61 μM.
更新日期：2018-10-01
京公网安备 11010802027423号