Numerous chemicals, such as phenolic compounds are strong radical scavengers, capable of alleviating oxidative stress induced neurodegeneration. Dietary antioxidants, especially flavonoids, are being considered as a promising approach to prevent or slow the pathological development of neurological illness and aging. One of the major advantage of natural products is that of their anti-amyloid effects over synthetic counterpart, however a healthy diet provides these beneficial natural substances as nutraceuticals. The extracellular-signal-regulated kinase (ERK) is one of the main pharmacological target of natural phenolic compounds, participating in several therapeutic effects. Mounting evidence revealed that numerous bioflavonoids, obtained from a variety of dietary fruits or plants as well as medicinal herbal sources, exhibit protective or therapeutic functions versus development of neurodegenerative diseases mainly through modulation of different compartments of ERK signaling pathway. Currently, there is remarkable interest in the beneficial effects of natural flavonoids to improve neural performance and prevent the onset and development of major neurodegenerative diseases. Natural products originated from medicinal plants, in particular antioxidants, have gained a great deal of attention due to their safe and non-toxic natures. Here, we summarized the effect of natural bioflavonoids on ERK signaling pathway and their molecular mechanism.

许多化学物质（例如酚类化合物）是强自由基清除剂，能够缓解氧化应激引起的神经变性。饮食中的抗氧化剂，尤其是类黄酮，被认为是预防或减缓神经系统疾病和衰老的病理发展的一种有前途的方法。天然产品的主要优点之一是其抗淀粉样蛋白作用优于合成同类产品，但是健康饮食可提供这些有益的天然物质作为保健食品。细胞外信号调节激酶（ERK）是天然酚类化合物的主要药理目标之一，参与多种治疗作用。越来越多的证据表明，从各种饮食水果或植物以及药用草药中获得的大量生物类黄酮，与神经退行性疾病的发展相比，其具有保护性或治疗性功能，主要是通过调节ERK信号通路的不同区室来实现的。当前，人们对天然类黄酮对改善神经功能并预防主要神经退行性疾病的发作和发展的有益作用引起了极大的兴趣。源自药用植物的天然产物，特别是抗氧化剂，由于其安全和无毒的性质而受到了广泛的关注。在这里，我们总结了天然生物类黄酮对ERK信号通路的影响及其分子机制。人们对天然类黄酮对改善神经功能，预防主要神经退行性疾病的发作和发展的有益作用产生了浓厚的兴趣。源自药用植物的天然产物，特别是抗氧化剂，由于其安全和无毒的性质而受到了广泛的关注。在这里，我们总结了天然生物类黄酮对ERK信号通路的影响及其分子机制。人们对天然类黄酮对改善神经功能，预防主要神经退行性疾病的发作和发展的有益作用产生了浓厚的兴趣。源自药用植物的天然产物，特别是抗氧化剂，由于其安全和无毒的性质而受到了广泛的关注。在这里，我们总结了天然生物类黄酮对ERK信号通路的影响及其分子机制。