Cancer is a relevant public health problem that represents the second leading cause of global death. In this regard, cisplatin is a highly effective antineoplastic drug used in treatment of several types of cancer, such as head and neck, testicular, ovarian, gastric, lung and breast cancer. Nevertheless, treatment with this compound leads to nephrotoxicity, which limits its use. Oxidative stress plays a pivotal role in cisplatin-induced renal damage and several dietary antioxidants have been reported to ameliorate this secondary effect. Relevant findings on the protective effects of these antioxidant agents in cisplatin-induced nephrotoxicity are summarized in this paper. Further, limitations of animal models used in these studies are discussed. Additionally, clinical studies on the protective effect of these antioxidants, as well as future directions for these kind of trials are also considered.

癌症是一个相关的公共健康问题，代表了全球死亡的第二大原因。在这方面，顺铂是用于治疗几种类型的癌症，例如头颈癌，睾丸癌，卵巢癌，胃癌，肺癌和乳腺癌的高效抗肿瘤药。然而，用该化合物治疗会导致肾毒性，从而限制了其用途。氧化应激在顺铂引起的肾损伤中起关键作用，据报道几种饮食抗氧化剂可改善这种次要作用。本文总结了有关这些抗氧化剂在顺铂诱导的肾毒性中的保护作用的相关发现。此外，讨论了在这些研究中使用的动物模型的局限性。此外，有关这些抗氧化剂的保护作用的临床研究，