The use of nanodiamonds in numerous materials designed for industry and medicine is growing rapidly. Consequently health and environmental risks associated with the exposure of humans and other biota to nanodiamonds-based materials are of the utmost importance. Scarcity of toxicological data for these particles led us to examine the potentially deleterious effects of nanodiamonds in model insect species, Acheta domesticus (Orthoptera) chronically exposed to ND in its diet. Organism-level end-point indices (lifespan, body weight, consumption, caloric value of faeces, reproduction) revealed adverse changes in the treated crickets in comparison with the control. Preliminary studies of oxidative stress level in the offspring of ND-treated crickets suggest toxicity of these particles limited to the exposed individuals. EPR analysis showing increase of radical signal in the faeces of ND-fed crickets led us to propose novel mechanism of nanodiamonds toxicity that is discussed in the light of literature data.

Capsule

Development and reproduction of Acheta domesticus can be disturbed by the chronic exposure to nanodiamonds

中文翻译：

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纳米金刚石的慢性毒性可能会干扰Acheta domesticus L的发育和繁殖

纳米金刚石在为工业和医学设计的多种材料中的使用正在迅速增长。因此，与人类和其他生物群接触基于纳米金刚石的材料有关的健康和环境风险至关重要。这些颗粒的毒理学数据稀缺，促使我们研究了纳米金刚石对模型昆虫Acheta domesticus的潜在有害作用。（直翅目）在饮食中长期暴露于ND。与对照组相比，生物体水平的终点指数（寿命，体重，消耗量，粪便的热值，繁殖）显示了处理过的的不利变化。ND处理的后代中氧化应激水平的初步研究表明，这些颗粒的毒性仅限于暴露的个体。EPR分析显示，在ND喂养的ec的粪便中自由基信号的增加，促使我们提出了纳米金刚石毒性的新机制，并根据文献数据对其进行了讨论。

胶囊

长期暴露于纳米金刚石可能会干扰家蝇的发育和繁殖