An efficient palladium/copper-catalyzed tandem Sonogashira reaction/lactonization of methyl 2-(2′,2′-dibromovinyl)benzoate with terminal alkynes has been developed. This facile and direct approach furnishes a variety of 3-alkynyl isocoumarins in moderate to good yields under mild reaction conditions. Furthermore, this method enables concise total synthesis of natural products 3′-hydroxycorfin and gymnopalynes A.

中文翻译：

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2-（2'，2'-二溴乙烯基）苯甲酸甲酯与末端炔烃的钯/铜催化串联Sonogashira偶联/内酯化：易于获得3-炔基异香豆素

已经开发了一种有效的钯/铜催化串联Sonogashira反应/ 2-（2'，2'-二溴乙烯基）苯甲酸甲酯与末端炔烃的内酯化。这种简便而直接的方法可在温和的反应条件下以中等至良好的产率提供各种3-炔基异香豆素。此外，该方法能够简明地完全合成天然产物3'-羟基皮质醇和裸gym草烯酮A。